(4-Fluorobenzyl)hydrazine

Base Information

• Chemical Name: (4-Fluorobenzyl)hydrazine
• CAS No.: 699-05-8
• Molecular Formula: C7H9FN2
• Molecular Weight: 140.16
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID10569375
• Wikidata: Q72479317
• Mol file: 699-05-8.mol

Synonyms:(4-fluorobenzyl)hydrazine;699-05-8;4-Fluorobenzylhydrazine;(4-fluorophenyl)methylhydrazine;[(4-fluorophenyl)methyl]hydrazine;(4-FLUORO-BENZYL)-HYDRAZINE;(4-fluorophenyl)methylhydrazine hydrochloride;4-fluorobenzyl hydrazine;SCHEMBL3984607;DTXSID10569375;YMMCBGIHBVKZGD-UHFFFAOYSA-N;MFCD06797341;AKOS000127987;PB20964;CS-0053727;EN300-29446;A26908;P10415;J-515401

Chemical Property of (4-Fluorobenzyl)hydrazine

Chemical Property:

• Boiling Point: 271.784 °C at 760 mmHg
• PKA: 7.28±0.70(Predicted)
• Flash Point: 118.171 °C
• PSA: 38.05000
• Density: 1.145 g/cm³
• LogP: 1.88020
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 140.07497646
• Heavy Atom Count: 10
• Complexity: 89.6

Purity/Quality:

99% ^*data from raw suppliers

(4-Fluorobenzyl)hydrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CNN)F
• Uses: (4-Fluorobenzyl)hydrazine can be used to treat pain and inflammation.

Technology Process of (4-Fluorobenzyl)hydrazine

There total 2 articles about (4-Fluorobenzyl)hydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-chloromethyl-4-fluorobenzene (352-11-4) → 4-fluorobenzyl hydrazine (699-05-8)

Guidance literature:

1-chloromethyl-4-fluorobenzene; With hydrazine; In ethanol; at 20 ℃; for 13h;

With sodium hydroxide; In diethyl ether; water;

Reference yield:

→ 4-fluorobenzyl hydrazine (699-05-8)

Guidance literature:

Reference yield: 96.0%

2-(2,4-dichlorophenoxy)propionic acid (120-36-5) + 4-fluorobenzyl hydrazine (699-05-8) → N'-(4-fluorobenzyl)-2-(2,4-dichlorophenoxy)propanehydrazide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2015.01.011

upstream raw materials:

1-chloromethyl-4-fluorobenzene

Downstream raw materials:

5-Amino-1-(4-fluorobenzyl)-4-cyanopyrazole

5-Amino-4-ethoxycarbonyl-1-(4-fluorobenzyl)pyrazole

1-(4-Fluorobenzyl)-7,8-dihydro-6H,9H-pyrazolo<3,4-b>quinoline-4,5-dione

4-Amino-1-(4-fluorobenzyl)-7,8-dihydro-6H-pyrazolo<3,4-b>quinolin-5-one

Refernces

• 1、 -. "HIV INTEGRASE INHIBITORS". Page/Page column 42-43. . Retrieved 2010/01/12.