1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER
• CAS No.: 6206-25-3
• Molecular Formula: C6H10O2
• Molecular Weight: 114.144
• Hs Code.: 2916209090
• Mol file: 6206-25-3.mol

Synonyms:1-Methylcyclopropane-1-carboxylic acid methyl ester;cyclopropanecarboxylic acid, 1-methyl-, methyl ester;

Chemical Property of 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Refractive Index: 1.4200 to 1.4230
• Boiling Point: 119.1 °C at 760 mmHg
• Flash Point: 19.9 °C
• PSA: 26.30000
• Density: 1.044 g/cm³
• LogP: 0.95950

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 1-Methylcyclopropane-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Statements: 10-20/21/22
• Safety Statements: 16-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER

There total 8 articles about 1-METHYLCYCLOPROPANE-1-CARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

diiodomethane (75-11-6) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 1-methylcyclopropanecarboxylate (6206-25-3)

Guidance literature:

With indium; In acetonitrile; at 25 ℃; for 3.75h;

DOI:10.1016/j.tetlet.2004.11.047

Reference yield: 76.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + methacrylic acid methyl ester (80-62-6,114512-63-9,143476-91-9,25188-98-1,9011-14-7) → methyl 1-methylcyclopropanecarboxylate (6206-25-3) + 3-methyl-3-methoxycarbonyl-4,5-dihydro-1H-pyrazole (6117-22-2)

Guidance literature:

palladium(II) acetylacetonate; In diethyl ether; at 0 ℃;

DOI:10.1007/BF00956960

Reference yield: 62.0%

3-methyl-3-methoxycarbonyl-4,5-dihydro-1H-pyrazole (6117-22-2) → methyl angelate (5953-76-4) + methyl (E)-2-methyl-2-butenoate (6622-76-0) + methyl 2-methyl-3-butenoate (51747-33-2) + methyl 1-methylcyclopropanecarboxylate (6206-25-3)

Guidance literature:

at 155 ℃; for 20h;

DOI:10.1021/jo00142a013

upstream raw materials:

diazomethane

methacrylic acid methyl ester

3-bromo-2-bromomethyl-2-methyl-propionic acid methyl ester

diiodomethane

Downstream raw materials:

1-methylcyclopropane-1-carbohydrazide

1-methylcyclopropanecarboximidamide hydrochloride

5-(1-methylcyclopropyl)isoxazol-3-ylamine

3-(1-methylcyclopropyl)-3-oxopropanenitrile

Refernces

• 1、 Chatgilialoglu, C.,Guerra, M.,Guerrini, A.,Seconi, G.,Clark, K. B.,et al.. "A Study on the Reducing Abilities of Tris(alkylthio)silanes". . p. 2427 - 2433. Retrieved 2007/10/02.
• 2、 -. "Process for cyclizing upsilon-chlorocarboxylic acids". . . Retrieved 2008/06/13.