TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE

Base Information

• Chemical Name: TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE
• CAS No.: 6138-26-7
• Molecular Formula: C9H14O6
• Molecular Weight: 218.2
• Hs Code.: 2917190090
• Mol file: 6138-26-7.mol

Synonyms:DIMETHYL 3-(METHOXYCARBONYL)PENTANEDIOATE;3-(METHOXYCARBONYL)PENTANEDIOIC ACID DIMETHYL ESTER;1,2,3-PROPANETRICARBOXYLIC ACID TRIMETHYL ESTER;TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE;TRICARBALLYLIC ACID TRIMETHYL ESTER;1,2,3-Propanetricarboxylicacidtrimethylester~Tricarballylicacidtrimethylester~Trimethyl3-carboxyglutarate~Trimeth

Chemical Property of TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE

Chemical Property:

• Refractive Index: nD20 1.4398
• Boiling Point: 150 °C / 13mmHg
• PSA: 78.90000
• Density: 1.18
• LogP: -0.09820
• Storage Temp.: Store below +30°C.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Trimethyl 1,2,3-Propanetricarboxylate >97.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE

There total 10 articles about TRIMETHYL 1,2,3-PROPANETRICARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + allyl isobutyl carbonate (167639-48-7) → 1,2,3-propanetricarboxylic acid trimethyl ester (6138-26-7)

Guidance literature:

With palladium(II) trifluoroacetate; N,N’-di(anthracen-9-yl)butane-2,3-diimine; toluene-4-sulfonic acid; p-benzoquinone; In tetrahydrofuran; at 20 ℃; for 67h; under 3000.3 Torr; Autoclave; Schlenk technique;

DOI:10.1002/cctc.202101923

Reference yield: 60.0%

isophorone oxide + Dimethyl succinate (106-65-0) + methyl iodide (74-88-4) → 1,2,3-propanetricarboxylic acid trimethyl ester (6138-26-7)

Guidance literature:

isophorone oxide; Dimethyl succinate; With 1-azabicyclo[2.2.2]octane borane adduct; trans-di-O-tert-butyl hyponitrite; In benzene; for 2.5h; Heating;

methyl iodide; With tetrabutyl ammonium fluoride; Further stages.;

DOI:10.1016/j.tetlet.2004.03.165

Reference yield:

→ 1,2,3-propanetricarboxylic acid trimethyl ester (6138-26-7)

Guidance literature:

With methanol; nickel; at 60 ℃; Hydrogenation;

upstream raw materials:

methanol

tricarallylic acid

prop-1-ene-1,2,3-tricarboxylic acid trimethyl ester

2,2-dimethoxy-propane

Downstream raw materials:

trimethyl 1-cyclohexylidenepropane-1,2,3-tricarboxylate

3,6-Dihydroxy-4-methoxycarbonylmethyl-phthalic acid

4,6-Dihydroxy-5,5-dimethoxy-cyclohexa-3,6-diene-1,2,3-tricarboxylic acid trimethyl ester

Refernces

• 1、 Olivieri, Diego,Tarroni, Riccardo,Della Ca', Nicola,Mancuso, Raffaella,Gabriele, Bartolo,Spadoni, Gilberto,Carfagna, Carla. "Combined Effect of Palladium Catalyst and the Alcohol to Promote the Uncommon Bis-Alkoxycarbonylation of Allylic Substrates". . . Retrieved 2022/03/01.