EXO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE

Base Information

• Chemical Name: EXO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE
• CAS No.: 6766-44-5
• Molecular Formula: C8H6O4
• Molecular Weight: 166.133
• Hs Code.: 2932999099
• Mol file: 6766-44-5.mol

Synonyms:7-OXABICYCLO[2.2.1]HEPT-5-ENE-2,3-DICARBOXYLIC ANHYDRIDE;

Chemical Property of EXO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE

Chemical Property:

• Melting Point: 118 °C (dec.)(lit.)
• Boiling Point: 372.0±42.0 °C(Predicted)
• PSA: 52.60000
• Density: 1.540±0.06 g/cm3(Predicted)
• LogP: -0.36060

Purity/Quality:

90%,98% ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of EXO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE

There total 2 articles about EXO-3,6-EPOXY-1,2,3,6-TETRAHYDROPHTHALIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

furan (110-00-9) + maleic anhydride (108-31-6) → 4,10-dioxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (5426-09-5,6118-51-0,6766-44-5)

Guidance literature:

at 20 ℃; for 24h;

DOI:10.1016/j.ejmech.2017.07.045

Reference yield:

furan (110-00-9) + maleic anhydride (108-31-6) → exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride (6118-51-0) + 7-oxabicyclo<2.2.1>heptene-exo-2,3-dicarboxylic anhydride (6766-44-5)

Guidance literature:

In acetone; at 20 ℃; for 282h; under 760 Torr; Kinetics; Product distribution; effect of high pressure: different pressures and times; rate constants; 40 deg C, deuteroacetonitrile;

DOI:10.1007/BF01168074

Reference yield: 93.0%

methanol (67-56-1) + 4,10-dioxatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione (5426-09-5,6118-51-0,6766-44-5) → 5,6-didehydronorcantharidin monomethyl ester

Guidance literature:

With boron trifluoride diethyl etherate; for 0.00833333h; further reagents;

DOI:10.1016/S0040-4020(99)00089-7

upstream raw materials:

furan

maleic anhydride

Downstream raw materials:

1,3-dioxo-decahydro-4,7-epioxido-benzo[3,4]cyclobuta[1,2-c]pyrrole-5,6-dicarboxylic acid anhydride

(3aR,4R,7S,7aS)-2-(benzyloxy)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione

endo-3a,4,7,7a-tetrahydro-4,7-epoxyisobenzofuran-1-(3H)-one

1,3-dioxo-decahydro-4,7-epioxido-benzo[3,4]cyclobuta[1,2-c]pyrrole-5,6-dicarboxylic acid dimethyl ester

Refernces

• 1、 -. "Homocamptothecin norcantharidinate derivative, and regioselective synthesis method thereof". Paragraph 0025; 0028-0029. . Retrieved 2019/11/21.
• 2、 Song, Mengyao,Ma, Hanbing,Ren, Minghan,Ai, Zhaoquan,Li, Ming. "Diacetylene-Based C 2h-Symmetric Monomers for Two-Dimensional-Polymer Synthesis". supporting information. p. 445 - 450. Retrieved 2017/02/24.