THIAZOLE-2-CARBOXYLIC ACID HYDRAZIDE

Base Information

• Chemical Name: THIAZOLE-2-CARBOXYLIC ACID HYDRAZIDE
• CAS No.: 16733-90-7
• Molecular Formula: C4H5 N3 O S
• Molecular Weight: 143.17
• Hs Code.: 2934100090
• Mol file: 16733-90-7.mol

Synonyms:1,3-Thiazole-2-carbohydrazide

Chemical Property of THIAZOLE-2-CARBOXYLIC ACID HYDRAZIDE

Chemical Property:

• Refractive Index: 1.626
• PSA: 96.25000
• Density: 1.437g/cm³
• LogP: 0.83780
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Thiazole-2-carboxylic acid hydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of THIAZOLE-2-CARBOXYLIC ACID HYDRAZIDE

There total 3 articles about THIAZOLE-2-CARBOXYLIC ACID HYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methyl thiazole-2-carboxylate → 1,3-thiazole-2-carbohydrazide (16733-90-7)

Guidance literature:

With hydrazine hydrate; In ethanol; water; at 20 ℃; for 2h;

Reference yield:

1,1-dimethylethyl 2-(1,3-thiazol-2-ylcarbonyl)hydrazinecarboxylate (1254073-54-5) → 1,3-thiazole-2-carbohydrazide (16733-90-7)

Guidance literature:

1,1-dimethylethyl 2-(1,3-thiazol-2-ylcarbonyl)hydrazinecarboxylate; With hydrogenchloride; In 1,4-dioxane; for 4h; Inert atmosphere;

With ammonia; In methanol;

Reference yield:

thiazole-2-carboxylic acid ethyl ester (14527-42-5) → 1,3-thiazole-2-carbohydrazide (16733-90-7)

Guidance literature:

With ethanol; hydrazine hydrate;

upstream raw materials:

thiazole-2-carboxylic acid ethyl ester

1,1-dimethylethyl 2-(1,3-thiazol-2-ylcarbonyl)hydrazinecarboxylate

Downstream raw materials:

7-[(2,3-dichlorophenyl)carbonyl]-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

7-[(3-chloro-4-fluoro-2-methylphenyl)carbonyl]-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

7-[(2,4-dichlorophenyl)carbonyl]-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

7-[(3-chloro-2-methylphenyl)carbonyl]-3-(1,3-thiazol-2-yl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine

Refernces

• 1、 -. "PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES AS A2A RECEPTOR ANTAGONIST". Paragraph 0619; 0623. . Retrieved 2019/11/04.
• 2、 -. "5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS". Page/Page column 87. . Retrieved 2010/11/17.