Methyl-3-(2-thienyl)=propionate

Base Information

• Chemical Name: Methyl-3-(2-thienyl)=propionate
• CAS No.: 16862-05-8
• Molecular Formula: C8H10O2S
• Molecular Weight: 170.232
• Hs Code.: 2934999090
• Mol file: 16862-05-8.mol

Synonyms:2-Thiophenepropionicacid, methyl ester (8CI);3-(Thiophen-2-yl)propionic acid methyl ester;Methyl2-thiophenepropanoate;Methyl 2-thiophenepropionate;Methyl 3-(2-thienyl)propionate;Methyl3-(2-thienyl)propanoate;

Chemical Property of Methyl-3-(2-thienyl)=propionate

Chemical Property:

• Vapor Pressure: 0.0744mmHg at 25°C
• Refractive Index: 1.522
• Boiling Point: 228.2 °C at 760 mmHg
• Flash Point: 91.8 °C
• PSA: 54.54000
• Density: 1.148g/cm³
• LogP: 1.85370
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-[2-Thienyl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 3-[2-Thienyl)propanoate (cas# 16862-05-8) is a compound useful in organic synthesis.

Technology Process of Methyl-3-(2-thienyl)=propionate

There total 12 articles about Methyl-3-(2-thienyl)=propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (E)-3-(2-thienyl)propenoate (57502-38-2) → methyl 3-(2-thienyl)propanoate (16862-05-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 11h; under 2327.2 Torr; Ambient temperature;

DOI:10.1021/jm00099a013

Reference yield: 98.0%

methanol (67-56-1) + 3-(2-thienyl)acrylic acid (15690-25-2,51019-83-1,1124-65-8) → methyl 3-(2-thienyl)propanoate (16862-05-8)

Guidance literature:

With 10% Pd/C; hydrogen; at 70 ℃; for 12h; under 4500.45 Torr;

DOI:10.2478/s11696-012-0222-7

Reference yield: 96.0%

methanol (67-56-1) + 3-(thiophen-2-yl)propanal (26359-21-7) → methyl 3-(2-thienyl)propanoate (16862-05-8)

Guidance literature:

With manganese(IV) oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-dimethyl-1,2,4-triazolium iodide; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol8018488

upstream raw materials:

methanol

3-(2-thienyl)propanoic acid

methyl (E)-3-(2-thienyl)propenoate

3-(2-thienyl)-2-propenoic acid

Downstream raw materials:

2-butyl-1-(4-carbomethoxybenzyl)-5-<2-carbomethoxy-1-hydroxy-3-(2-thienyl)propyl>imidazole

methyl 3-[2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-yl]-3-hydroxy-2-[(thien-2-yl)methyl]propanoate

5,6-dihydro-<6H>-cyclopenta--thiophene-4-one

5,6-dihydro-4H-cyclopenta[b]thiophen-4-ol

Refernces

• 1、 ?zen, Bilal,Fadaei Tirani, Farzaneh,Schenk, Kurt,Lin, Kun-Han,Scopelliti, Rosario,Corminboeuf, Clémence,Frauenrath, Holger. "Structure–Property Relationships in Bithiophenes with Hydrogen-Bonded Substituents". . p. 3348 - 3360. Retrieved 2021.
• 2、 Fedorova, Natalia E.,Godovikov, Ivan A.,Klimova, Regina R.,Kraevaya, Olga A.,Kushch, Alla A.,Mishchenko, Denis V.,Peregudov, Alexander S.,Schols, Dominique,Shestakov, Alexander F.,Troshin, Pavel A.. "Thiophene-based water-soluble fullerene derivatives as highly potent antiherpetic pharmaceuticals". . p. 8702 - 8708. Retrieved 2020.
• 3、 MacHara, Ales,Svoboda, Jiri. "Thiophenium-ylides: Synthesis and reactivity". . p. 59 - 65,7. Retrieved 2020/08/24.