Technology Process of L-Proline, 4-hydroxy-1-nitroso-, methyl ester, trans- (9CI)
There total 2 articles about L-Proline, 4-hydroxy-1-nitroso-, methyl ester, trans- (9CI) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
acetic acid; sodium nitrite;
In
water;
at 0 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/jm5009049
- Guidance literature:
-
With
acetic acid; sodium nitrite;
In
water;
at 0 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 1H-imidazole / dichloromethane / 25 °C / Inert atmosphere
2.1: lithium triethylborohydride / tetrahydrofuran / 5 h / -78 - 25 °C / Inert atmosphere
3.1: zinc; ammonium chloride; water / methanol / 1.5 h / 0 - 50 °C / Inert atmosphere
4.1: acetic acid / 3 h / 25 °C / Inert atmosphere
5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C / Inert atmosphere
6.1: boron trifluoride diethyl etherate / dichloromethane / 3 h / 0 - 25 °C / Inert atmosphere
7.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
7.2: 2 h / 0 - 25 °C / Inert atmosphere
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 0 - 25 °C / Inert atmosphere
9.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 25 °C / Inert atmosphere
10.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 18 h / 0 - 25 °C / Inert atmosphere
With
1H-imidazole; oxalyl dichloride; lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; sodium hydride; lithium triethylborohydride; ammonium chloride; acetic acid; dimethyl sulfoxide; triphenylphosphine; zinc;
In
tetrahydrofuran; methanol; dichloromethane; water;
5.1: |Swern Oxidation;
DOI:10.1021/jm5009049