2-Thiophenepropanoicacid,alpha-amino-5-ethyl-,ethylester(9CI)

Base Information

• Chemical Name: 2-Thiophenepropanoicacid,alpha-amino-5-ethyl-,ethylester(9CI)
• CAS No.: 603945-33-1
• Molecular Formula: C₁₁H₁₇NO₂S
• Molecular Weight: 227.327
• Mol file: 603945-33-1.mol

Synonyms:2-Thiophenepropanoicacid,alpha-amino-5-ethyl-,ethylester(9CI)

Chemical Property of 2-Thiophenepropanoicacid,alpha-amino-5-ethyl-,ethylester(9CI)

Chemical Property:

• PSA: 80.56000
• LogP: 2.44370

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Thiophenepropanoicacid,alpha-amino-5-ethyl-,ethylester(9CI)

There total 5 articles about 2-Thiophenepropanoicacid,alpha-amino-5-ethyl-,ethylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethyl 3-(5-ethylthiophen-2-yl)-2-(hydroxyimino)propanoate → ethyl 2-amino-3-(5-ethylthiophen-2-yl)propanoate (603945-33-1)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; water; at 0 ℃; for 3h;

DOI:10.3762/bjoc.14.264

Reference yield: 92.0%

→ ethyl 2-amino-3-(5-ethylthiophen-2-yl)propanoate (603945-33-1)

Guidance literature:

With hydrogenchloride; zinc; In ethanol; for 2h;

Reference yield:

5-ethyl-thiophene-2-carbaldehyde (36880-33-8) → ethyl 2-amino-3-(5-ethylthiophen-2-yl)propanoate (603945-33-1)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic acid; piperidine / ethanol / 10 h / 60 °C / Inert atmosphere; Molecular sieve

2: ethanol; sodium tetrahydroborate / 0 °C

3: sodium ethanolate; isopentyl nitrite / ethanol / 2 h / 0 °C / Molecular sieve

4: hydrogenchloride; zinc / ethanol; water / 3 h / 0 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; ethanol; sodium ethanolate; acetic acid; zinc; isopentyl nitrite; In ethanol; water; 1: |Knoevenagel Condensation;

DOI:10.3762/bjoc.14.264

upstream raw materials:

5-ethyl-thiophene-2-carbaldehyde

Refernces

• 1、 -. "IMIDAZOPYRAZINE DERIVATIVES, PROCESS FOR PREPARATION THEREOF, AND THEIR USES AS LUCIFERINS". Page/Page column 60-61. . Retrieved 2018/11/22.