5-chloro-2-fluorobenzamidine

Base Information

• Chemical Name: 5-chloro-2-fluorobenzamidine
• CAS No.: 674793-32-9
• Molecular Formula: C7H6ClFN2
• Molecular Weight: 172.589
• Mol file: 674793-32-9.mol

Synonyms:5-chloro-2-fluorobenzamidine;5-chloro-2-fluorobenzimidamide;2-Fluoro-5-chlorobenzamidine;5-chloro-2-fluorobenzimidamide hydrochloride;BenzenecarboxiMidaMide, 5-chloro-2-fluoro-

Chemical Property of 5-chloro-2-fluorobenzamidine

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.577
• Boiling Point: 255.197 °C at 760 mmHg
• Flash Point: 108.14 °C
• PSA: 49.87000
• Density: 1.41g/cm³
• LogP: 2.56320

Purity/Quality:

98%min ^*data from raw suppliers

5-chloro-2-fluorobenzamidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2-fluorobenzamidine

There total 2 articles about 5-chloro-2-fluorobenzamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

5-chloro-2-fluorobenzonitrile (57381-34-7) → 2-fluoro-5-chlorobenzamidine (674793-32-9)

Guidance literature:

5-chloro-2-fluorobenzonitrile; With n-butyllithium; 1,1,1,3,3,3-hexamethyl-disilazane; In hexanes; diethyl ether; at 0 - 20 ℃; for 2.08333h;

With hydrogenchloride; water; In hexanes; diethyl ether; at 0 ℃; for 0.5h;

With sodium hydroxide; In hexanes; diethyl ether; water; pH=14; Product distribution / selectivity;

Reference yield:

5-chloro-2-fluorobenzonitrile (57381-34-7) + lithium hexamethyldisilazane (4039-32-1) → 2-fluoro-5-chlorobenzamidine (674793-32-9)

Guidance literature:

In diethyl ether; Product distribution / selectivity;

Reference yield: 78.0%

2-fluoro-5-chlorobenzamidine (674793-32-9) + 2-(methoxycarbonyl)cyclohexanone (41302-34-5) → 2-(5-chloro-2-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-4-ol (773140-34-4)

Guidance literature:

In ethanol; at 80 ℃;

upstream raw materials:

5-chloro-2-fluorobenzonitrile

lithium hexamethyldisilazane

Downstream raw materials:

2-(5-chloro-2-fluoro-phenyl)-6,6-dimethyl-6,7-dihydro-5H-cyclopentapyrimidin-4-ol

2-(5-chloro-2-fluorophenyl)-5,6,7,8-tetrahydroquinazolin-4-ol

2-(5-chloro-2-fluorobenzyl)-5-cyclopropyl-pyrimidone

2-(5-chloro-2-fluorophenyl)-5-isopropylpyrimidine-4-one

Refernces

• 1、 -. "HETEROBICYLIC INHIBITORS OF HCV". Page/Page column 28. . Retrieved 2008/06/13.
• 2、 -. "INHIBITORS OF TFGβ". Page/Page column 22. . Retrieved 2010/02/06.