3-Pyridinecarboxylicacid,6-amino-2-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinecarboxylicacid,6-amino-2-methyl-(9CI)
• CAS No.: 680208-82-6
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.15
• Hs Code.: 2933399090
• Mol file: 680208-82-6.mol

Synonyms:3-Pyridinecarboxylicacid,6-amino-2-methyl-(9CI);6-Amino-2-methylpyridine-3-carboxylic acid

Chemical Property of 3-Pyridinecarboxylicacid,6-amino-2-methyl-(9CI)

Chemical Property:

• Vapor Pressure: 1.67E-05mmHg at 25°C
• Refractive Index: 1.627
• Boiling Point: 350℃
• PKA: 2.86±0.25(Predicted)
• Flash Point: 166℃
• PSA: 76.21000
• Density: 1.337
• LogP: 1.25160
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Amino-2-methylnicotinic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylicacid,6-amino-2-methyl-(9CI)

There total 2 articles about 3-Pyridinecarboxylicacid,6-amino-2-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-amino-5-cyano-6-methylpyridine (183428-90-2) → 6-amino-2-methylpyridine-3-carboxylic acid? (680208-82-6)

Guidance literature:

2-amino-5-cyano-6-methylpyridine; With potassium hydroxide; water; for 72h; Heating / reflux;

With hydrogenchloride; water; at 20 ℃;

Reference yield:

5-bromo-6-methyl-pyridin-2-ylamine (42753-71-9) → 6-amino-2-methylpyridine-3-carboxylic acid? (680208-82-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 96 h / 130 °C

1.2: 85 °C

2.1: sulfuric acid / 1 h / 100 °C

2.2: 5 h

With sulfuric acid; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide;

Reference yield: 91.0%

methanol (67-56-1) + 6-amino-2-methylpyridine-3-carboxylic acid? (680208-82-6) → methyl 6-amino-2-methylpyridine-3-carboxylate (872355-52-7)

Guidance literature:

With thionyl chloride; at 80 ℃; for 15h;

DOI:10.1016/j.bmc.2021.116514

upstream raw materials:

2-amino-5-cyano-6-methylpyridine

5-bromo-6-methyl-pyridin-2-ylamine

Downstream raw materials:

methyl 6-amino-2-methylpyridine-3-carboxylate

ethyl 6-amino-2-methylpyridine-3-carboxylate

6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester

6-methyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid

Refernces

• 1、 -. "AMINOALCOHOL SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS". Page/Page column 54. . Retrieved 2012/05/31.
• 2、 -. "ALKOXY-SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINES". Page/Page column 59. . Retrieved 2012/05/31.