1-FLUORO-4-((E)-STYRYL)-BENZENE

Base Information

• Chemical Name: 1-FLUORO-4-((E)-STYRYL)-BENZENE
• CAS No.: 718-25-2
• Molecular Formula: C14H11F
• Molecular Weight: 198.24
• Mol file: 718-25-2.mol

Synonyms:1-FLUORO-4-((E)-STYRYL)-BENZENE

Chemical Property of 1-FLUORO-4-((E)-STYRYL)-BENZENE

Chemical Property:

• Vapor Pressure: 0.00433mmHg at 25°C
• Refractive Index: 1.639
• Boiling Point: 287.3°C at 760 mmHg
• Flash Point: 124.2°C
• PSA: 0.00000
• Density: 1.12g/cm³
• LogP: 3.99610

Purity/Quality:

99% ^*data from raw suppliers

1-FLUORO-4-((E)-STYRYL)-BENZENE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-FLUORO-4-((E)-STYRYL)-BENZENE

There total 159 articles about 1-FLUORO-4-((E)-STYRYL)-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

iodobenzene (591-50-4) + para-fluorostyrene (405-99-2) → (E)-4-fluorostilbene (718-25-2)

Guidance literature:

With di-μ-iodobis(tri-tert-butylphosphino)dipalladium(l); N-ethyl-N,N-diisopropylamine; In toluene; at 100 ℃; for 15h; Inert atmosphere; Sealed tube; Glovebox;

DOI:10.1055/s-0036-1588318

Reference yield: 99.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 4-fluoro-1-iodobenzene (352-34-1) → (E)-4-fluorostilbene (718-25-2)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,5-di(2,4,6-trimethylphenyl)-1,2,5-thiadiazolidine-1-oxide; triethylamine; In N,N-dimethyl-formamide; at 200 ℃; for 0.166667h; Microwave irradiation;

DOI:10.1016/j.tet.2010.08.018

Reference yield: 99.0%

para-fluorostyrene (405-99-2) + Diphenyliodonium triflate (66003-76-7) → (E)-4-fluorostilbene (718-25-2)

Guidance literature:

With palladium diacetate; In N,N-dimethyl-formamide; at 130 ℃; for 0.0333333h; regioselective reaction; Schlenk technique; Microwave irradiation;

DOI:10.2174/1570178611310010011

upstream raw materials:

4-fluoro-1-iodobenzene

1--1-phenylethene

4-fluorobenzaldehyde

benzyl chloride

Downstream raw materials:

1-Adamant-1-yl-2-(p-fluorphenyl)-1-phenylethan

1-Adamant-1-yl-1-(p-fluorphenyl)-2-phenylethan

(4-fluorophenyl)phenylethanedione

3-Fluorophenanthrene

Refernces

• 1、 Zhang, Kena,Provot, Olivier,Alami, Mouad,Tran, Christine,Hamze, Abdallah. "Pd-Catalyzed Coupling of N-Tosylhydrazones with Benzylic Phosphates: Toward the Synthesis of Di- or Tri-Substituted Alkenes". . p. 1249 - 1261. Retrieved 2022/02/07.
• 2、 Guo, Zhifen,Liu, Xin,Che, Yan,Chen, Dashu,Xing, Hongzhu. "One-Pot Dual Catalysis of a Photoactive Coordination Polymer and Palladium Acetate for the Highly Efficient Cross-Coupling Reaction via Interfacial Electron Transfer". supporting information. p. 2695 - 2705. Retrieved 2022/02/14.