2,6-Dichloro-4-hydroxybenzaldehyde

Base Information

• Chemical Name: 2,6-Dichloro-4-hydroxybenzaldehyde
• CAS No.: 60964-09-2
• Molecular Formula: C7H4Cl2O2
• Molecular Weight: 191.014
• Hs Code.: 2913000090
• Mol file: 60964-09-2.mol

Synonyms:2,6-Dichloro-4-hydroxybenzaldehyde

Chemical Property of 2,6-Dichloro-4-hydroxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.000844mmHg at 25°C
• Melting Point: 227-229°C
• Refractive Index: 1.643
• Boiling Point: 295.8 °C at 760 mmHg
• PKA: 5.87±0.23(Predicted)
• Flash Point: 132.7 °C
• PSA: 37.30000
• Density: 1.547 g/cm³
• LogP: 2.51150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Air Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%Min ^*data from raw suppliers

2,6-Dichloro-4-hydroxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: As starting reagents proposed to use 4-hydroxy-2,6-dimethylbenzaldehyde and 2,6-dichloro-4-hydroxybenzaldehyde easily available by straightforward syntheses from commercial products.

Technology Process of 2,6-Dichloro-4-hydroxybenzaldehyde

There total 13 articles about 2,6-Dichloro-4-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,6-dichloro-4-hydroxybenzaldehyde (60964-09-2)

Guidance literature:

3-chloro-5-[(triisopropylsilyl)oxy]phenyl chloride; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - -10 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; water;

Reference yield: 80.0%

1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene (126663-61-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,6-dichloro-4-hydroxybenzaldehyde (60964-09-2)

Guidance literature:

1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene; With sec.-butyllithium; In tetrahydrofuran; at -70 - -68 ℃; for 2.25h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -70 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃;

Reference yield: 78.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 3-chloro-5-[(triisopropylsilyl)oxy]phenyl chloride (216257-25-9) → 2,6-dichloro-4-hydroxybenzaldehyde (60964-09-2)

Guidance literature:

3-chloro-5-[(triisopropylsilyl)oxy]phenyl chloride; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

N,N-dimethyl-formamide; In tetrahydrofuran; at -78 - 20 ℃; for 0.05h; Inert atmosphere;

With hydrogenchloride; In water; at 20 ℃; for 1h;

upstream raw materials:

chloroform

3,5-dichlorophenol

1-<(tert-butyldimethylsilyl)oxy>-3,5-dichlorobenzene

N,N-dimethyl-formamide

Downstream raw materials:

3,5-dichloro-4-formyl-phenyl trifluoromethanesulfonate

2,6-dichloro-4-(2-phthalimidoethoxy)benzaldehyde

5-[2,6-dichloro-4-(chloroacetoxy)phenyl]dipyrromethane

5-[2,6-dichloro-4-(2-phthalimidoethoxy)phenyl]dipyrromethane

Refernces

• 1、 -. "NOVEL THYROMIMETICS". . . Retrieved 2020/09/19.
• 2、 -. "DERIVATIVES OF SOBETIROME". . . Retrieved 2017/12/15.