ethyl 2-(2-hydroxybenzoyl)benzoate

Base Information

• Chemical Name: ethyl 2-(2-hydroxybenzoyl)benzoate
• CAS No.: 7494-43-1
• Molecular Formula: C16H14O4
• Molecular Weight: 270.28
• Mol file: 7494-43-1.mol

Synonyms:Ethyl 2-(2-hydroxybenzoyl)benzoate;

Chemical Property of ethyl 2-(2-hydroxybenzoyl)benzoate

Chemical Property:

• Vapor Pressure: 2.5E-06mmHg at 25°C
• Refractive Index: 1.589
• Boiling Point: 380.4 °C at 760 mmHg
• PKA: 7.59±0.30(Predicted)
• Flash Point: 137.2 °C
• PSA: 63.60000
• Density: 1.226 g/cm³
• LogP: 2.79990

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(2-hydroxybenzoyl)benzoate

There total 3 articles about ethyl 2-(2-hydroxybenzoyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N'-[Bis-(2-hydroxy-phenyl)-methylene]-hydrazinecarboxylic acid ethyl ester → ethyl 2-(2-hydroxybenzoyl)benzoate (7494-43-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1080/00304949609458576

Reference yield: 47.0%

ethyl 2-benzoylbenzoate (604-61-5) → ethyl 2-(2-hydroxybenzoyl)benzoate (7494-43-1)

Guidance literature:

With dipotassium peroxodisulfate; palladium diacetate; trifluoroacetic acid; trifluoroacetic anhydride; at 80 ℃; for 9h; regioselective reaction; Sealed tube;

DOI:10.1002/anie.201207458

Reference yield:

ethanol (64-17-5) + 2-hydroxybenzoylbenzoic acid (6079-73-8) → ethyl 2-(2-hydroxybenzoyl)benzoate (7494-43-1)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethanol

2-hydroxybenzoylbenzoic acid

ethyl 2-benzoylbenzoate

Refernces

• 1、 Shan, Gang,Yang, Xinglin,Ma, Linlin,Rao, Yu. "Pd-catalyzed C-H oxygenation with TFA/TFAA: Expedient access to oxygen-containing heterocycles and late-stage drug modification". supporting information. p. 13070 - 13074. Retrieved 2013/02/26.