5-(6-HYDROXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-YL)-2-METHYL-PENTANOIC ACID

Base Information

• Chemical Name: 5-(6-HYDROXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-YL)-2-METHYL-PENTANOIC ACID
• CAS No.: 7083-09-2
• Molecular Formula: C19H28O4
• Molecular Weight: 320.42322
• Mol file: 7083-09-2.mol

Synonyms:5-(6-HYDROXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-YL)-2-METHYL-PENTANOIC ACID

Chemical Property of 5-(6-HYDROXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-YL)-2-METHYL-PENTANOIC ACID

Chemical Property:

• Vapor Pressure: 8.94E-11mmHg at 25°C
• Refractive Index: 1.532
• Boiling Point: 499°C at 760 mmHg
• Flash Point: 174.6°C
• PSA: 66.76000
• Density: 1.098g/cm³
• LogP: 4.29210

Purity/Quality:

99% ^*data from raw suppliers

(±)-α-CMBHC ≥98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: (±)-α-CMBHC is a metabolite of (±)-α-tocopherol .

Technology Process of 5-(6-HYDROXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-YL)-2-METHYL-PENTANOIC ACID

There total 5 articles about 5-(6-HYDROXY-2,5,7,8-TETRAMETHYL-CHROMAN-2-YL)-2-METHYL-PENTANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid methyl ester (7047-69-0) → (+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid (7083-09-2)

Guidance literature:

With sodium hydroxide; In methanol; water; for 2h; Heating;

DOI:10.1016/S0968-0896(01)00010-4

Reference yield:

6-oxo-2-methyl-heptanoic acid (2570-68-5) → (+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid (7083-09-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 76 percent / sulphuric acid / 2 h / Heating

2: 81 percent / tetrahydrofuran / 2 h / 0 °C

3: 80 percent / BF₃*Et₂O / dioxane / 110 °C

4: 48 percent / sodium hydroxide / H₂O; methanol / 2 h / Heating

With sodium hydroxide; sulfuric acid; boron trifluoride diethyl etherate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 2: Grignard reaction;

DOI:10.1016/S0968-0896(01)00010-4

Reference yield:

6-oxo-2-methyl-heptanoic acid methyl ester (2570-90-3) → (+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid (7083-09-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / tetrahydrofuran / 2 h / 0 °C

2: 80 percent / BF₃*Et₂O / dioxane / 110 °C

3: 48 percent / sodium hydroxide / H₂O; methanol / 2 h / Heating

With sodium hydroxide; boron trifluoride diethyl etherate; In tetrahydrofuran; 1,4-dioxane; methanol; water; 1: Grignard reaction;

DOI:10.1016/S0968-0896(01)00010-4

upstream raw materials:

(+/-)-5-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-2-methyl-pentanoic acid methyl ester

6-oxo-2-methyl-heptanoic acid

6-oxo-2-methyl-heptanoic acid methyl ester

6-hydroxy-6-vinyl-2-methyl-heptanoic acid methyl ester

Refernces