3-Bromo-1H-pyrazolo[4,3-b]pyridine

Base Information

• Chemical Name: 3-Bromo-1H-pyrazolo[4,3-b]pyridine
• CAS No.: 633328-33-3
• Molecular Formula: C6H4BrN3
• Molecular Weight: 198.022
• Hs Code.: 2933990090
• Mol file: 633328-33-3.mol

Synonyms:1H-Pyrazolo[4, 3-b]pyridine, 3-bromo-;

Chemical Property of 3-Bromo-1H-pyrazolo[4,3-b]pyridine

Chemical Property:

• Vapor Pressure: 2.99E-05mmHg at 25°C
• Refractive Index: 1.745
• Boiling Point: 366.9 °C at 760 mmHg
• PKA: 8.76±0.40(Predicted)
• Flash Point: 175.7 °C
• PSA: 41.57000
• Density: 1.894 g/cm³
• LogP: 1.72040
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Bromo-1h-pyrazolo[4,3-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Bromo-1H-pyrazolo[4,3-b]pyridine

There total 3 articles about 3-Bromo-1H-pyrazolo[4,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-pyrazolo-[4,3-b]-pyridine (272-52-6) → 3-bromo-1H-pyrazolo[4,3-b]pyridine (633328-33-3)

Guidance literature:

1H-pyrazolo-[4,3-b]-pyridine; With bromine; sodium hydroxide; In water; at 20 ℃; for 3h;

With hydrogenchloride; sodium hydrogensulfite; In water;

Reference yield:

3-fluoropyridine-2-carbaldehyde (31224-43-8) → 3-bromo-1H-pyrazolo[4,3-b]pyridine (633328-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / 16 h / 110 °C

2: sodium hydroxide; bromine / water / 3 h / 20 °C

With bromine; sodium hydroxide; hydrazine; In water;

Reference yield:

→ 3-bromo-1H-pyrazolo[4,3-b]pyridine (633328-33-3)

Guidance literature:

upstream raw materials:

3-fluoropyridine-2-carbaldehyde

1H-pyrazolo-[4,3-b]-pyridine

Downstream raw materials:

tert-butyl 3-((3-chlorophenyl)amino)-1H-pyrazolo[4,3-b]pyridine-1-carboxylate

N-(3-chlorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine

N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine

1H-pyrazolo[4,3-b]pyridine-3-carbonitrile

Refernces

• 1、 -. "ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS". Paragraph 0086. . Retrieved 2013/05/21.
• 2、 -. "PYRAZOLOPYRIDINE, PYRAZOLOPYRAZINE, PYRAZOLOPYRIMIDINE, PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION". . . Retrieved 2011/09/15.