1-Cyclobutylethanol

Base Information

• Chemical Name: 1-Cyclobutylethanol
• CAS No.: 7515-29-9
• Molecular Formula: C6H12O
• Molecular Weight: 100.161
• Hs Code.: 2906199090
• Mol file: 7515-29-9.mol

Synonyms:1-CYCLOBUTYLETHANOL;1-Hydroxyethylcyclobutane;α-Methylcyclobutanemethanol;a-Methylcyclobutanemethanol;1-cyclobutylethan-1-ol

Chemical Property of 1-Cyclobutylethanol

Chemical Property:

• Vapor Pressure: 2.02mmHg at 25°C
• Refractive Index: 1.473
• Boiling Point: 144.5 °C at 760 mmHg
• Flash Point: 57.9 °C
• PSA: 20.23000
• Density: 0.962 g/cm³
• LogP: 1.16730
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-Cyclobutylethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Cyclobutylethanol is a compound useful in organic synthesis.

Technology Process of 1-Cyclobutylethanol

There total 6 articles about 1-Cyclobutylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

cyclobutylaldehyde (2987-17-9) + methylmagnesium bromide (75-16-1) → cyclobutylmethylcarbinol (7515-29-9)

Guidance literature:

In diethyl ether; at -78 - -15 ℃; for 1h; Inert atmosphere;

DOI:10.1039/d0cc00767f

Reference yield:

2-(3-Bromo-propyl)-3-methyl-oxirane (121416-57-7) → cyclobutylmethylcarbinol (7515-29-9) + trans-2-methylcyclopentanol (25144-04-1)

Guidance literature:

With copper(l) iodide; lithium dihydronaphthylide radical; triphenylphosphine; In toluene; Yield given. Yields of byproduct given; 1) -45 deg C, 5 min, -23 deg C, 3 h, r.t.;

DOI:10.1016/0040-4020(89)80072-9

Reference yield:

1-cyclobutylethanone (3019-25-8) → cyclobutylmethylcarbinol (7515-29-9)

Guidance literature:

With lithium aluminium tetrahydride; diethyl ether;

upstream raw materials:

1-cyclobutylethanone

cis-6-bromo-2,3-epoxyhexane

2-(3-Bromo-propyl)-3-methyl-oxirane

diethyl ether

Downstream raw materials:

1-methylcyclopent-1-ene

Refernces

• 1、 Cheang, Daniella M. J.,Armstrong, Roly J.,Akhtar, Wasim M.,Donohoe, Timothy J.. "Enantioconvergent alkylation of ketones with racemic secondary alcohols: Via hydrogen borrowing catalysis". supporting information. p. 3543 - 3546. Retrieved 2020/04/03.
• 2、 Wu, Tse-Chong,Rieke, Reuben D.. "DIRECT FORMATION OF EPOXYALKYLCOPPER REAGENTS FROM ACTIVATED COPPER AND EPOXYALKYL BROMIDES AND THEIR INTRAMOLECULAR CYCLIZATIONS". . p. 6753 - 6756. Retrieved 2007/10/02.