Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester
• CAS No.: 62596-26-3
• Molecular Formula: C14H16O3
• Molecular Weight: 232.279
• Mol file: 62596-26-3.mol

Synonyms:Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester

Chemical Property of Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester

Chemical Property:

• PSA: 43.37000
• LogP: 2.48910

Purity/Quality:

99%min ^*data from raw suppliers

Benzyl 4-oxocyclohexanecarboxylate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester

There total 8 articles about Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-oxocyclohexanecarboxylic acid (874-61-3) + benzyl bromide (100-39-0) → benzyl 4-oxocyclohexane-1-carboxylate (62596-26-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

Reference yield: 83.0%

4-oxo-bicyclo[3.1.0]hexane-1-carboxylic acid benzyl ester (216106-48-8) → benzyl 4-oxocyclohexane-1-carboxylate (62596-26-3)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; methanol; for 0.0333333h; Ambient temperature;

DOI:10.1016/S0040-4039(98)01749-3

Reference yield: 67.0%

benzyl 4-hydroxycyclohexane-1-carboxylate (123762-06-1) → benzyl 4-oxocyclohexane-1-carboxylate (62596-26-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; at 20 ℃;

DOI:10.2298/JSC150430063O

upstream raw materials:

(±)-benzyl cyclohex-3-ene-1-carboxylate

4-oxo-bicyclo[3.1.0]hexane-1-carboxylic acid benzyl ester

benzyl 4-hydroxycyclohexane-1-carboxylate

4-oxocyclohexanecarboxylic acid

Downstream raw materials:

benzyl 4-fluoro-cyclohex-3-ene-1-carboxylate

C₁₆H₂₃NO₂

C₁₇H₁₉Cl₂N₅O₄

C₂₄H₂₅Cl₂N₅O₄

Refernces

• 1、 -. "SUBSTITUTED BICYCLIC COMPOUNDS AS FARNESOID X RECEPTOR MODULATORS". Page/Page column 288-289. . Retrieved 2020/08/28.
• 2、 -. "DIHYDROPYRIMIDINE DERIVATIVES AND USES THEREOF IN THE TREATMENT OF HBV INFECTION OR OF HBV-INDUCED DISEASES". Page/Page column 63. . Retrieved 2019/11/28.