1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER

Base Information

• Chemical Name: 1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER
• CAS No.: 63001-31-0
• Molecular Formula: C₇H₈N₂O₃
• Molecular Weight: 168.152
• Hs Code.: 2933990090
• Mol file: 63001-31-0.mol

Synonyms:1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER;

Chemical Property of 1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER

Chemical Property:

• Melting Point: 127-128 °C
• Boiling Point: 381.8 °C at 760 mmHg
• PKA: 10.41±0.40(Predicted)
• Flash Point: 184.7 °C
• PSA: 72.05000
• Density: 1.33 g/cm³
• LogP: -0.05340
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 6-hydroxypyridazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER

There total 9 articles about 1,6-DIHYDRO-6-OXO-3-PYRIDAZINECARBOXYLIC ACID, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

6-oxo-1,6-dihydropyridazine-3-carboxylic acid (37972-69-3) + ethanol (64-17-5) → ethyl 1,6-dihydro-6-oxopyridazine-3-carboxylate (63001-31-0)

Guidance literature:

With hydrogenchloride; for 14h; Reflux;

DOI:10.1016/j.ejmech.2017.05.060

Reference yield: 52.5%

ethanol (64-17-5) + 6-hydroxy-pyridazine-3-carboxylic acid (37972-69-3) → 6-hydroxy-3-pyridazinecarboxylic acid ethyl ester (63001-31-0)

Guidance literature:

With hydrogenchloride; for 14h; Heating;

DOI:10.1248/cpb.42.371

Reference yield: 41.0%

ethyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate (89943-56-6) → ethyl 1,6-dihydro-6-oxopyridazine-3-carboxylate (63001-31-0)

Guidance literature:

With thionyl chloride; In ethanol; at 90 ℃; for 1h; Sealed tube;

DOI:10.1016/j.tet.2013.03.037

upstream raw materials:

ethyl 6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxylate

diethyl 2-diazopentanedioate

6-oxo-1,6-dihydropyridazine-3-carboxylic acid

ethanol

Downstream raw materials:

6-chloro-3-pyridazinecarboxylic acid ethyl ester

Refernces

• 1、 -. "Pyridazine derivative and preparation method and application thereof". Paragraph 0240; 0241. . Retrieved 2017/02/17.
• 2、 Morishita,Kobayashi,Yamada,Yajima. "Synthesis of 3-chloropyridazine-6-carboxylic acid hydrazide and selective hydrazinolysis of 3,6-substituted pyridazines". . p. 371 - 372. Retrieved 2007/10/02.