2-Chloro-6-hydrazinylpyrazine

Base Information

• Chemical Name: 2-Chloro-6-hydrazinylpyrazine
• CAS No.: 63286-29-3
• Molecular Formula: C4H5ClN4
• Molecular Weight: 144.564
• Hs Code.: 2933990090
• European Community (EC) Number: 811-999-5
• DSSTox Substance ID: DTXSID80507103
• Nikkaji Number: J1.734.113H
• Wikidata: Q72451691
• Mol file: 63286-29-3.mol

Synonyms:2-Chloro-6-hydrazinylpyrazine;63286-29-3;2-chloro-6-hydrazinopyrazine;(6-chloropyrazin-2-yl)hydrazine;1-(6-chloropyrazin-2-yl)hydrazine;MFCD09049072;2(1H)-Pyrazinone, 6-chloro-, hydrazone;SCHEMBL6658388;OSM-S-302;DTXSID80507103;FEDQSVIJHNBUHH-UHFFFAOYSA-N;(6-Chloro-pyrazin-2-yl)-hydrazine;AKOS000133032;AKOS028109071;PS-5637;SY065959;CS-0099498;EN300-31188;A846908;Z319443864

Chemical Property of 2-Chloro-6-hydrazinylpyrazine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 118 °C
• Refractive Index: 1.684
• Boiling Point: 310.576 °C at 760 mmHg
• Flash Point: 141.632 °C
• PSA: 63.83000
• Density: 1.53 g/cm³
• LogP: 1.18890
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 144.0202739
• Heavy Atom Count: 9
• Complexity: 88.6

Purity/Quality:

97% purity ^*data from raw suppliers

2-Chloro-6-hydrazinylpyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(C=N1)Cl)NN

Technology Process of 2-Chloro-6-hydrazinylpyrazine

There total 2 articles about 2-Chloro-6-hydrazinylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-dichloropyrazine (4774-14-5) → 2-chloro-6-hydrazinopyridazine (63286-29-3)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃;

DOI:10.1021/acs.jmedchem.0c00746

Reference yield:

→ 2-chloro-6-hydrazinopyridazine (63286-29-3)

Guidance literature:

2,6-Dichlorpyrazin, NH2-NH2;

DOI:10.1021/jo00862a005

Reference yield: 95.0%

4-nitrobenzaldehdye (555-16-8) + 2-chloro-6-hydrazinopyridazine (63286-29-3) → 5-chloro-3-(4-nitrophenyl)[1,2,4]triazolo[4,3-a]pyrazine

Guidance literature:

In ethanol; Reflux;

DOI:10.1021/acs.joc.0c01045

upstream raw materials:

2,6-dichloropyrazine

Refernces

• 1、 -. "HERBICIDAL COMPOUNDS". Page/Page column 104. . Retrieved 2021/04/02.
• 2、 Korsik, Marat,Tse, Edwin G.,Smith, David G.,Lewis, William,Rutledge, Peter J.,Todd, Matthew H.. "tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3- a]pyrazine-Based Antimalarials". . p. 13438 - 13452. Retrieved 2020/12/15.