5-METHYL-2-NITROBENZONITRILE

Base Information

• Chemical Name: 5-METHYL-2-NITROBENZONITRILE
• CAS No.: 64113-86-6
• Molecular Formula: C8H6N2O2
• Molecular Weight: 162.148
• Hs Code.: 2926909090
• Mol file: 64113-86-6.mol

Synonyms:5-Methyl-2-nitrobenzonitrile;

Chemical Property of 5-METHYL-2-NITROBENZONITRILE

Chemical Property:

• Vapor Pressure: 9.52E-05mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 338.9 °C at 760 mmHg
• Flash Point: 158.8 °C
• PSA: 69.61000
• Density: 1.26 g/cm³
• LogP: 2.29808
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

5-Methyl-2-nitrobenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-2-NITROBENZONITRILE

There total 12 articles about 5-METHYL-2-NITROBENZONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-methyl-2-nitrobenzamide (4315-12-2) → 2-nitro-5-methylbenzonitrile (64113-86-6)

Guidance literature:

With trichlorophosphate; In DMF (N,N-dimethyl-formamide); at -10 - 100 ℃; for 1.25h;

Reference yield: 79.0%

C8H8N2O3 (1448721-86-5) → 2-nitro-5-methylbenzonitrile (64113-86-6)

Guidance literature:

With pyridinium chlorochromate; In chloroform; for 3h; Reflux;

DOI:10.1080/00397911.2012.738459

Reference yield: 55.0%

→ 2-nitro-5-methylbenzonitrile (64113-86-6)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; for 0.5h;

DOI:10.1016/0022-328X(95)05553-2

upstream raw materials:

(5-methyl-2-nitro-phenyl)-pyruvic acid

3-Methylbenzonitrile

5-methyl-2-nitrobenzamide

copper(I) cyanide

Downstream raw materials:

5-methyl-2-nitrobenzamide

C₂₀H₂₁NO₅S

5-(bromomethyl)-2-nitrobenzonitrile

2-fluoro-5-methylbenzonitrile

Refernces

• 1、 Chandrappa,Prasanna,Vinaya,Prasanna,Rangappa. "PCC-Promoted dehydration of aldoximes: A convenient access to aromatic, heteroaromatic, and aliphatic nitriles". . p. 2756 - 2762. Retrieved 2013/08/23.
• 2、 -. "CRYSTALLINE SALT FORMS OF ANTIFOLATE COMPOUNDS AND METHODS OF MANUFACTURING THEREOF". Page/Page column 19-20. . Retrieved 2009/10/17.