3-hydroxyphenobarbital

Base Information

• Chemical Name: 3-hydroxyphenobarbital
• CAS No.: 427-17-8
• Molecular Formula: C₁₂H₁₂N₂O₄
• Molecular Weight: 248.238
• Hs Code.: 2933540000
• Mol file: 427-17-8.mol

Synonyms:Barbituricacid, 5-ethyl-5-(m-hydroxyphenyl)- (7CI,8CI); m-Hydroxyphenobarbital

Chemical Property of 3-hydroxyphenobarbital

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 102.48000
• Density: 1.33g/cm³
• LogP: 0.95780

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-hydroxyphenobarbital

There total 5 articles about 3-hydroxyphenobarbital which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-ethyl-5-(3-hydroxy-phenyl)-barbituric acid (427-17-8)

Guidance literature:

With water;

DOI:10.1021/ja01299a017

Reference yield:

5-ethyl-5-(3-oxo-cyclohex-1-enyl)-pyrimidine-2,4,6-trione (35305-10-3) → 5-ethyl-5-(3-hydroxy-phenyl)-barbituric acid (427-17-8)

Guidance literature:

With palladium on activated charcoal;

Reference yield:

5-ethyl-5-(3-methoxy-phenyl)-pyrimidine-2,4,6-trione (2957-61-1) → 5-ethyl-5-(3-hydroxy-phenyl)-barbituric acid (427-17-8)

Guidance literature:

With hydrogen bromide;

upstream raw materials:

5-ethyl-5-(3-oxo-cyclohex-1-enyl)-pyrimidine-2,4,6-trione

5-ethyl-5-(3-methoxy-phenyl)-pyrimidine-2,4,6-trione

2-(3-methoxyphenyl)malonic acid diethyl ester

ethyl-(3-methoxy-phenyl)-malonic acid diethyl ester