4-HYDROXY-7-DIETHIAMINO-COUMARINE

Base Information

• Chemical Name: 4-HYDROXY-7-DIETHIAMINO-COUMARINE
• CAS No.: 64369-55-7
• Molecular Formula: C13H15 N O3
• Molecular Weight: 233.267
• Hs Code.: 2932209090
• Mol file: 64369-55-7.mol

Synonyms:7-(Diethylamino)-4-hydroxycoumarin;7-Diethylamino-4-hydroxy-2-oxo-2H-chromene

Chemical Property of 4-HYDROXY-7-DIETHIAMINO-COUMARINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 236 °C(Solv: isopropanol (67-63-0))
• Refractive Index: 1.627
• Boiling Point: 432.685°C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 215.48°C
• PSA: 53.68000
• Density: 1.274g/cm³
• LogP: 2.34480

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Diethylamino-4-hydroxy-chromen-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Has applications involving cholinesterase inhibitors for β-amyloid plaques as well as synthesis of fluorescent dyes based on coumarin.

Technology Process of 4-HYDROXY-7-DIETHIAMINO-COUMARINE

There total 7 articles about 4-HYDROXY-7-DIETHIAMINO-COUMARINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

malonic acid bis-(2,4,6-trichloro-phenyl) ester (15781-70-1) + 3-diethylaminophenol (91-68-9) → 7-(diethylamino)-4-hydroxy-2H-chromen-2-one (64369-55-7)

Guidance literature:

In toluene; at 110 ℃; for 4h;

DOI:10.1002/chem.201402306

Reference yield: 91.0%

diphenyl malonate (1969-44-4) + 3-diethylaminophenol (91-68-9) → 7-(diethylamino)-4-hydroxy-2H-chromen-2-one (64369-55-7)

Guidance literature:

In toluene; for 12h; Reflux;

Reference yield: 74.0%

bis-2,4-dichlorophenyl malonate (52994-51-1) + 3-diethylaminophenol (91-68-9) → 7-(diethylamino)-4-hydroxy-2H-chromen-2-one (64369-55-7)

Guidance literature:

In toluene; for 2h; Heating;

DOI:10.1002/jhet.5570170204

upstream raw materials:

bis-2,4-dichlorophenyl malonate

3-diethylaminophenol

malonic acid bis-(2,4,6-trichloro-phenyl) ester

diphenyl malonate

Downstream raw materials:

4-chloro-7-(diethylamino)-3-((1E)-3-oxo-3-phenylprop-1-en-1-yl)-2H-chromen-2-one

4-azido-7-(diethylamino)-3-((1E)-3-oxo-3-phenylprop-1-en-1-yl)-2H-chromen-2-one

Refernces

• 1、 Yin, Guo-Xing,Niu, Ting-Ting,Gan, Ya-Bing,Yu, Ting,Yin, Peng,Chen, Hai-Min,Zhang, You-Yu,Li, Hai-Tao,Yao, Shou-Zhuo. "A Multi-signal Fluorescent Probe with Multiple Binding Sites for Simultaneous Sensing of Cysteine, Homocysteine, and Glutathione". . p. 4991 - 4994. Retrieved 2018.
• 2、 Feng, Xi,Qin, Zhen,Cheng, Xinying,Liu, Dongyu,Peng, Yinghe,Huang, Huidan,Song, Bin,Bian, Jinlei,Li, Zhiyu. "Copper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2- c]coumarin Derivatives and Evaluation for Photophysical Properties". supporting information. p. 12537 - 12548. Retrieved 2021/09/20.
• 3、 -. "Thienocoumarin-based ratio-type probe and preparation and application thereof". Paragraph 0045-0048. . Retrieved 2021/11/10.