2-AMINO-5-NITROPYRIDINE

Base Information

• Chemical Name: 2-AMINO-5-NITROPYRIDINE
• CAS No.: 67476-67-9
• Molecular Formula: C₅H₅N₃O₂
• Molecular Weight: 139.114
• Mol file: 67476-67-9.mol

Synonyms:2-Amino-5-Nitro Pyridine; 2-Pyridinamine,5-nitro; 5-Nitro-2-aminopyridine; 5-nitropyridin-2-amin; 5-Nitro-2-pyridinamine; 5-nitro-pyridin-2-yl amine; 查看更多英文别名 收起

Chemical Property of 2-AMINO-5-NITROPYRIDINE

Chemical Property:

• PSA: 84.73000
• LogP: 1.67640

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-NITROPYRIDINE

There total 36 articles about 2-AMINO-5-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-bromo-5-nitropyridine (4487-59-6) → 5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9)

Guidance literature:

With copper(I) oxide; ammonia; at 80 ℃; for 16h;

DOI:10.1016/S0040-4039(01)00458-0

Reference yield: 98.0%

2-Fluoro-5-nitropyridine (456-24-6) → 5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9)

Guidance literature:

With acetamidine hydrochloride; sodium hydroxide; In water; dimethyl sulfoxide; at 130 ℃; for 24h; chemoselective reaction; Schlenk technique;

DOI:10.1039/c8ob02129e

Reference yield: 91.67%

2-aminopyridine (504-29-0) → 5-nitro-pyridin-2-ylamine (4214-76-0,67476-67-9)

Guidance literature:

With sulfuric acid; nitric acid; In 1,2-dichloro-ethane; at 58 ℃; for 10h; Concentration; Temperature;

upstream raw materials:

2-aminopyridine

2-amino-5-nitro-nicotinic acid

3-nitropyridine

2-chloro-5-nitropyridine

Downstream raw materials:

ethyl 2-methyl-6-nitroimidazo[1,2-a]pyridine-3-carboxylate

(5-nitro-[2]pyridyl)-imidophosphoric acid triphenyl ester

N-(4-chloro-phenyl)-N'-(5-nitro-[2]pyridyl)-urea

1-(5-nitropyridin-2-yl)-3-phenylurea

Refernces

• 1、 Wang, Weisi,Yao, Junmin,Chen, Zhuo,Sun, Yiming,Shi, Yuqing,Wei, Yufen,Zhou, Hejun,Yu, Yingfang,Li, Shizhu,Duan, Liping. "Methnaridine is an orally bioavailable, fast-killing and long-acting antimalarial agent that cures Plasmodium infections in mice". supporting information. p. 5569 - 5579. Retrieved 2020/11/03.
• 2、 Amangasieva,Borovlev,Demidov,Avakyan,Borovleva. "Synthesis of Amides by Nucleophilic Substitution of Hydrogen in 3-Nitropyridine". . p. 867 - 872. Retrieved 2018/07/31.