4-PIPERAZIN-1-YL-PHENYLAMINE

Base Information

• Chemical Name: 4-PIPERAZIN-1-YL-PHENYLAMINE
• CAS No.: 67455-41-8
• Molecular Formula: C10H15 N3
• Molecular Weight: 177.249
• Hs Code.: 2933599090
• Mol file: 67455-41-8.mol

Synonyms:1-(4-Aminophenyl)piperazine;4-(1-Piperazinyl)aniline; 4-(1-Piperazinyl)benzenamine;4-(4-Aminophenyl)piperazine; NSC 149520

Chemical Property of 4-PIPERAZIN-1-YL-PHENYLAMINE

Chemical Property:

• Vapor Pressure: 5.56E-06mmHg at 25°C
• Melting Point: 119-123oC(lit.)
• Boiling Point: 380.2oC at 760 mmHg
• PKA: 9.12±0.10(Predicted)
• Flash Point: 183.7oC
• PSA: 41.29000
• Density: 1.107g/cm3
• LogP: 1.65340

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(4-Aminophenyl)piperazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Piperazinoaniline(CAS#67455-41-8)is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.

Technology Process of 4-PIPERAZIN-1-YL-PHENYLAMINE

There total 11 articles about 4-PIPERAZIN-1-YL-PHENYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(4-Nitrophenyl)piperazine (6269-89-2) → 4-(piperazin-1-yl)aniline (67455-41-8)

Guidance literature:

With hydrazine hydrate; at 90 ℃; for 1.66667h; chemoselective reaction;

DOI:10.1080/00397911.2010.523159

Reference yield: 16.0%

→ 4-(piperazin-1-yl)aniline (67455-41-8) + acridin-9-yl-[4-(piperazine-1-yl)phenyl]amine (80259-17-2)

Guidance literature:

Reference yield:

4-chlorobenzonitrile (100-00-5) → 4-(piperazin-1-yl)aniline (67455-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / 12 h / 120 °C

2: 95 percent / NH₄O₂CH / Pd/C / methanol / Heating

With ammonium formate; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium on activated charcoal; In methanol; dimethyl sulfoxide; 1: Arylation / 2: Reduction;

DOI:10.1016/S0040-4039(99)01103-X

upstream raw materials:

1-(4-Nitrophenyl)piperazine

para-dinitrobenzene

4-chlorobenzonitrile

para-nitrophenyl bromide

Downstream raw materials:

2-((5-chloro-2-((4-(piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzamide

4-[4-(4-nitro-phenyl)-piperazin-1-yl]-phenylamine

Refernces

• 1、 -. "Methylene violet derivative fluorescent probe as well as synthesis method and application thereof". Paragraph 0052-0054; 0057. . Retrieved 2021/03/13.
• 2、 Wang, Yang,Chen, Xing,Yan, Yaoyao,Zhu, Xiaochen,Liu, Mingming,Liu, Xinhua. "Discovery and SARs of 5-Chloro- N4-phenyl- N2-(pyridin-2-yl)pyrimidine-2,4-diamine Derivatives as Oral Available and Dual CDK 6 and 9 Inhibitors with Potent Antitumor Activity". . p. 3327 - 3347. Retrieved 2020/04/08.