7-Ethoxy-2-naphthalenol

Base Information

• Chemical Name: 7-Ethoxy-2-naphthalenol
• CAS No.: 57944-44-2
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID60482343
• Nikkaji Number: J1.849.764F
• Wikidata: Q72471843
• Mol file: 57944-44-2.mol

Synonyms:7-Ethoxy-2-naphthalenol;57944-44-2;7-ethoxynaphthalen-2-ol;7-ethoxy-2-naphthol;7-Ethoxy-2-hydroxynaphthalene;MFCD11110689;2-Naphthalenol,7-ethoxy-(9CI);2-Naphthalenol,7-ethoxy-;SCHEMBL741708;DTXSID60482343;JUCJMPYFZSOWCE-UHFFFAOYSA-N;AKOS009314780;DS-0637;FS-2901;SY039189;AM20040763;CS-0044817;FT-0646351;A831679;J-519236;(3-BOC-AMINO-PIPERIDIN-1-YL)-PYRIDIN-4-YL-ACETICACID

Chemical Property of 7-Ethoxy-2-naphthalenol

Chemical Property:

• Vapor Pressure: 2.68E-05mmHg at 25°C
• Refractive Index: 1.622
• Boiling Point: 347.5 °C at 760 mmHg
• PKA: 9.47±0.40(Predicted)
• Flash Point: 209.8 °C
• PSA: 29.46000
• Density: 1.158 g/cm³
• LogP: 2.94410
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 188.083729621
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

98%min ^*data from raw suppliers

7-Ethoxy-2-naphthalenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC2=C(C=CC(=C2)O)C=C1

Technology Process of 7-Ethoxy-2-naphthalenol

There total 4 articles about 7-Ethoxy-2-naphthalenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-acetyloxy-2-ethoxynaphthalene → 7-ethoxy-2-naphthol (57944-44-2)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 25 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.202004671

Reference yield:

2-acetoxy-7-hydroxynaphthalene (146744-23-2) → 7-ethoxy-2-naphthol (57944-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 24 h / Reflux

2: potassium hydroxide / tetrahydrofuran; water / 24 h / 25 °C / Inert atmosphere

With potassium carbonate; potassium hydroxide; In tetrahydrofuran; water; acetone;

DOI:10.1002/anie.202004671

Reference yield:

2,7-Dihydroxynaphthalene (582-17-2) → 7-ethoxy-2-naphthol (57944-44-2)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 6 h / 0 - 25 °C

2: potassium carbonate / acetone / 24 h / Reflux

3: potassium hydroxide / tetrahydrofuran; water / 24 h / 25 °C / Inert atmosphere

With potassium carbonate; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; acetone;

DOI:10.1002/anie.202004671

upstream raw materials:

diethyl sulfate

2,7-Dihydroxynaphthalene

2-acetoxy-7-hydroxynaphthalene

Refernces

• 1、 Ermili,Mazzei,Roma,Cuttica,Passerini. "Chemical and pharmacological researches on derivatives of 1H naphtho [2,1 b] pyran. IV". . p. 870 - 883. Retrieved 2007/10/10.