1-DIFLUOROMETHYL-2-PHENYL-IMIDAZOLE

Base Information

• Chemical Name: 1-DIFLUOROMETHYL-2-PHENYL-IMIDAZOLE
• CAS No.: 220173-84-2
• Molecular Formula: C₁₀H₈F₂N₂
• Molecular Weight: 194.184
• Mol file: 220173-84-2.mol

Synonyms:1-(Difluoromethyl)-2-phenyl-1H-imidazole;1-Difluoromethyl-2-phenyl-imidazole;

Chemical Property of 1-DIFLUOROMETHYL-2-PHENYL-IMIDAZOLE

Chemical Property:

• Vapor Pressure: 0.00297mmHg at 25°C
• Refractive Index: 1.55
• Boiling Point: 284.5 °C at 760 mmHg
• Flash Point: 125.8 °C
• PSA: 17.82000
• Density: 1.23 g/cm³
• LogP: 2.94520

Purity/Quality:

98%Min ^*data from raw suppliers

1-(difluoromethyl)-2-phenyl-1H-Imidazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-DIFLUOROMETHYL-2-PHENYL-IMIDAZOLE

There total 13 articles about 1-DIFLUOROMETHYL-2-PHENYL-IMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-Bromodifluoromethyl-2-phenylimidazole (341529-06-4) → 1-(difluoromethyl)-2-phenyl-1H-imidazole (220173-84-2)

Guidance literature:

With water; zinc; In methanol; at 20 ℃; for 24h;

DOI:10.1016/S0022-1139(01)00390-6

Reference yield: 81.0%

2-Phenylimidazole (670-96-2) + (trifluoromethyl)trimethylsilane (81290-20-2) → 1-(difluoromethyl)-2-phenyl-1H-imidazole (220173-84-2)

Guidance literature:

With lithium iodide; In Triethylene glycol dimethyl ether; at 170 ℃; for 1.5h; Time; Inert atmosphere; Microwave irradiation;

DOI:10.1021/ol403007j

Reference yield: 76.0%

2-Phenylimidazole (670-96-2) + 2,2‐difluoro‐2‐(triphenylphosphonio)acetate → 1-(difluoromethyl)-2-phenyl-1H-imidazole (220173-84-2)

Guidance literature:

In para-xylene; at 90 ℃; for 2h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c5cc02736e

upstream raw materials:

2-Phenylimidazole

Chlorodifluoromethane

metyhyl chlorodifluoroacetate

1-Bromodifluoromethyl-2-phenylimidazole

Refernces

• 1、 Surya Prakash,Krishnamoorthy, Sankarganesh,Ganesh, Somesh K.,Kulkarni, Aditya,Haiges, Ralf,Olah, George A.. "N -difluoromethylation of imidazoles and benzimidazoles using the ruppert-prakash reagent under neutral conditions". . p. 54 - 57. Retrieved 2014.
• 2、 Mao, Ting,Zhao, Liang,Huang, Yang,Lou, Yue-Guang,Yao, Qiuli,Li, Xiao-Fei,He, Chun-Yang. "N-Difluoromethylation of imidazoles and pyrazoles using BrCF2PO(OEt)2 under mild condition". supporting information. p. 2752 - 2754. Retrieved 2018/06/12.