(R)-3-Aminodihydrofuran-2,5-dione hydrochloride

Base Information

• Chemical Name: (R)-3-Aminodihydrofuran-2,5-dione hydrochloride
• CAS No.: 143394-93-8
• Molecular Formula: C₄H₅NO₃*ClH
• Molecular Weight: 151.55
• Hs Code.: 2922399090
• Mol file: 143394-93-8.mol

Synonyms:(R)-3-Aminodihydrofuran-2,5-dione hydrochloride;

Chemical Property of (R)-3-Aminodihydrofuran-2,5-dione hydrochloride

Chemical Property:

• Vapor Pressure: 0.000392mmHg at 25°C
• Boiling Point: 312.4 °C at 760 mmHg
• Flash Point: 142.7 °C
• PSA: 69.39000
• LogP: 0.28950
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

(R)-3-Aminodihydrofuran-2,5-dionehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-3-Aminodihydrofuran-2,5-dione hydrochloride

There total 2 articles about (R)-3-Aminodihydrofuran-2,5-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → (S)-3-amino-3,4-dihydrofurane-2,5-dione hydrochloride (34029-31-7,143394-93-8,39185-99-4)

Guidance literature:

With phosphorus trichloride; In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-2001-14563

Reference yield:

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + phosphorus trichloride (7719-12-2,52843-90-0) → (S)-3-amino-3,4-dihydrofurane-2,5-dione hydrochloride (34029-31-7,143394-93-8,39185-99-4)

Guidance literature:

With acetic anhydride; In propionic acid;

Reference yield: 71.7%

methanol (67-56-1) + (S)-3-amino-3,4-dihydrofurane-2,5-dione hydrochloride (34029-31-7,143394-93-8,39185-99-4) → H-Asp-OMe (17812-32-7,65414-77-9,65414-78-0,89495-37-4)

Guidance literature:

methanol; (S)-3-amino-3,4-dihydrofurane-2,5-dione hydrochloride; at 20 ℃; for 10h; Large scale;

With triethylamine; at 30 ℃; pH=7 - 8; Large scale;

upstream raw materials:

L-Aspartic acid

phosphorus trichloride

Downstream raw materials:

H-Asp-OMe

Refernces

• 1、 -. "Preparation method of N -fluorenylmethoxycarbonyl - L -aspartic -4 -tert-butyl ester". Paragraph 0013; 0027-0029; 0036-0038. . Retrieved 2021/08/25.
• 2、 Yan, Gexin,Wu, Yong,Lin, Wenqing,Zhang, Xiaomei. "Synthesis of novel chiral oxazoline ligands and application in the highly enantioselective diethylzinc addition to N-diphenylphosphinoylimines". . p. 2643 - 2648. Retrieved 2008/04/05.