3-(P-BENZYLOXYPHENYL)-DL-BETA-ALANINE

Base Information

• Chemical Name: 3-(P-BENZYLOXYPHENYL)-DL-BETA-ALANINE
• CAS No.: 330645-19-7
• Molecular Formula: C16H17NO3
• Molecular Weight: 271.12
• Hs Code.: 2922509090
• Mol file: 330645-19-7.mol

Synonyms:3-Amino-3-(4-phenylmethoxyphenyl)propanoic acid;

Chemical Property of 3-(P-BENZYLOXYPHENYL)-DL-BETA-ALANINE

Chemical Property:

• Vapor Pressure: 2.72E-09mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 460.9 °C at 760 mmHg
• Flash Point: 232.6 °C
• PSA: 72.55000
• Density: 1.219 g/cm³
• LogP: 3.44040
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-3-[4-(benzyloxy)phenyl]propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(P-BENZYLOXYPHENYL)-DL-BETA-ALANINE

There total 2 articles about 3-(P-BENZYLOXYPHENYL)-DL-BETA-ALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-benzyloxybenzaldehyde (4397-53-9) + malonic acid (141-82-2) → (RS)-3-amino-3-(4-benzyloxyphenyl)propanoic acid (330645-19-7,218278-65-0,218608-77-6)

Guidance literature:

With ammonium acetate; In ethanol; for 5h; Heating;

Reference yield: 64.0%

p-benzyloxybenzaldehyde (4397-53-9) + malonic acid (141-82-2) → (E)-4-benzyloxycinnamic acid (6272-45-3,227105-11-5) + (RS)-3-amino-3-(4-benzyloxyphenyl)propanoic acid (330645-19-7,218278-65-0,218608-77-6)

Guidance literature:

With ammonium acetate; In butan-1-ol; Heating;

DOI:10.1007/s11176-005-0377-9

Reference yield: 85.0%

methanol (67-56-1) + (RS)-3-amino-3-(4-benzyloxyphenyl)propanoic acid (330645-19-7,218278-65-0,218608-77-6) → methyl (RS)-3-amino-3-(4-benzyloxyphenyl)propanoate hydrochloride

Guidance literature:

With thionyl chloride; at 0 ℃; for 48h;

upstream raw materials:

p-benzyloxybenzaldehyde

malonic acid

Refernces

• 1、 Lebedev,Lebedeva,Sheludyakov,Kovaleva,Ustinova,Kozhevnikov. "Competitive formation of β-amino acids, propenoic, and ylidenemalonic acids by the Rodionov reaction from malonic acid, aldehydes, and ammonium acetate in alcoholic medium". . p. 1113 - 1124. Retrieved 2007/10/03.