2-Aminocyclohexanone

Base Information

• Chemical Name: 2-Aminocyclohexanone
• CAS No.: 22374-48-7
• Molecular Formula: C6H11NO
• Molecular Weight: 113.159
• Hs Code.: 2922399090
• Mol file: 22374-48-7.mol

Synonyms:2-aminocyclohexanone;

Chemical Property of 2-Aminocyclohexanone

Chemical Property:

• Boiling Point: 213.9 °C at 760 mmHg
• Flash Point: 83.2 °C
• PSA: 43.09000
• Density: 1.023 g/cm³
• LogP: 1.15710

Purity/Quality:

99% ^*data from raw suppliers

2-AMINOCYCLOHEXANONE 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Aminocyclohexanone

There total 10 articles about 2-Aminocyclohexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(cyclohex-1-en-1-yloxy)-1,1-dimethyl-N,N-bis(trimethylsilyl)silanamine (1638623-33-2) → 2-aminocyclohexanone (22374-48-7)

Guidance literature:

With [bis(acetoxy)iodo]benzene; In dichloromethane; at 25 ℃; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400405

Reference yield:

2-aminocyclohexanol (6850-38-0) → 2-aminocyclohexanone (22374-48-7)

Guidance literature:

With oxovanadium(IV) sulfate; 2-azatricyclo[3.3.1.1^3,7]dec-2-yloxidanyl; oxygen; propiononitrile; at 80 ℃; for 4h; under 1500.15 Torr;

Reference yield:

1-(cyclohex-1-en-1-yloxy)-1,1-dimethyl-N,N-bis(trimethylsilyl)silanamine (1638623-33-2) → (S)-2-aminocyclohexanone + trans-2-aminocyclohexanol (22374-48-7)

Guidance literature:

With (2,6-bis(((R)-1-(mesitylamino)-1-oxopropan-2-yl)oxy)-phenyl)-λ³-iodanediyl diacetate; In dichloromethane; acetonitrile; at 25 ℃; Overall yield = 87 %; Overall yield = 31 mg; stereoselective reaction; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201400405

upstream raw materials:

cyclohexane-1,2-dione monooxime

C₇H₁₂Cl₂N₂O

cyclohexanone

C₈H₁₅ClOSi

Downstream raw materials:

2-methoxy-6-methylsulfanyl-N-(2-oxo-cyclohexyl)-4-trifluoromethyl-benzamide

(1R,2R)-2-(Benzhydryl-amino)-1-(1-phenyl-vinyl)-cyclohexanol

(1S,2R)-2-(Benzhydryl-amino)-1-(1-phenyl-vinyl)-cyclohexanol

2-<(Diphenylmethylidene)amino>cyclohexanone

Refernces

• 1、 Mizar, Pushpak,Wirth, Thomas. "Flexible stereoselective functionalizations of ketones through umpolung with hypervalent iodine reagents". . p. 5993 - 5997. Retrieved 2014/06/10.