3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione

Base Information

• Chemical Name: 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione
• CAS No.: 1031393-48-2
• Molecular Formula: C₂₇H₃₀F₆N₂O₄
• Molecular Weight: 560.537
• Mol file: 1031393-48-2.mol

Synonyms:

Chemical Property of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione

There total 14 articles about 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C29H34F6N2O5 → 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione (1031393-48-2)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃;

DOI:10.1016/j.bmcl.2015.04.080

Reference yield:

toluene (108-88-3,15644-74-3,16713-13-6) → 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione (1031393-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride; carbonic acid dimethyl ester / 20 °C

2: water; ethanol / 70 °C

3: N,N-dimethyl-formamide / 20 °C

4: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; aluminum (III) chloride; carbonic acid dimethyl ester; In ethanol; water; ethyl acetate; N,N-dimethyl-formamide; 1: |Friedel-Crafts Acylation / 2: |Bucherer-Bergs Reaction;

DOI:10.1016/j.bmcl.2015.04.080

Reference yield:

methyl 4-hydroxylbenzoate (99-76-3,156291-94-0) → 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione (1031393-48-2)

Guidance literature:

Multi-step reaction with 12 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

2: N,N-dimethyl-aniline / 18 h / 210 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 2 h / 0 - 80 °C

5: sodium hydroxide / water; ethanol / 2 h / 0 °C / Reflux

6: thionyl chloride / 2 h / Reflux

7: tetramethylammonium fluoride / 1,2-dimethoxyethane / -78 - 20 °C / Inert atmosphere

8: sodium hydride / tetrahydrofuran / 0 - 20 °C

9: hydrogen; palladium 10% on activated carbon / methanol / 20 °C

10: potassium carbonate / N,N-dimethyl-formamide / 20 °C

11: N,N-dimethyl-formamide / 20 °C

12: hydrogenchloride / ethyl acetate / 20 °C

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; tetramethylammonium fluoride; hydrogen; sodium hydride; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; water; ethyl acetate; N,N-dimethyl-aniline; N,N-dimethyl-formamide; 2: |Claisen Rearrangement;

DOI:10.1016/j.bmcl.2015.04.080

upstream raw materials:

5-(4-bromophenyl)-5-methyl-3-(oxiran-2-ylmethyl)imidazolidine-2,4-dione

1-(4-bromobutoxy)-4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-n-propylbenzene

toluene

methyl 4-hydroxylbenzoate

Refernces