2,6-Diiodopyrazine

Base Information

• Chemical Name: 2,6-Diiodopyrazine
• CAS No.: 58138-79-7
• Molecular Formula: C4H2 I2 N2
• Molecular Weight: 331.882
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00451477
• Wikidata: Q72467241
• Mol file: 58138-79-7.mol

Synonyms:2,6-Diiodopyrazine;58138-79-7;MFCD09265492;2,6-Diiodo-pyrazine;SCHEMBL1830625;2 pound not6-DIIODOPYRAZINE;2,6-Diiodopyrazine, AldrichCPR;OSM-S-660;DTXSID00451477;XDGFMLMNWQGILQ-UHFFFAOYSA-N;AKOS015853857;CS-W003615;DS-10486;SY029874;AM20070421;FT-0650208;A23450;EN300-201066;J-507490

Chemical Property of 2,6-Diiodopyrazine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.737
• Boiling Point: 329.733 °C at 760 mmHg
• PKA: -2.62±0.10(Predicted)
• Flash Point: 153.217 °C
• PSA: 25.78000
• Density: 2.765 g/cm³
• LogP: 1.68580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 331.83074
• Heavy Atom Count: 8
• Complexity: 70.4

Purity/Quality:

99% ^*data from raw suppliers

2,6-Diiodopyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(N=C(C=N1)I)I

Technology Process of 2,6-Diiodopyrazine

There total 2 articles about 2,6-Diiodopyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2,6-dichloropyrazine (4774-14-5) → 2,6-diiodopyrazine (58138-79-7)

Guidance literature:

With hydrogen iodide; sodium iodide; In water; at 100 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201504113

Reference yield: 19.0%

→ 2,6-diiodopyrazine (58138-79-7)

Guidance literature:

Reference yield: 100.0%

2,6-diiodopyrazine (58138-79-7) → 2-iodo-6-methoxypyrazine (58139-03-0)

Guidance literature:

With sodium methylate; sodium; In methanol;

upstream raw materials:

2,6-dichloropyrazine

Downstream raw materials:

2-iodo-6-methoxypyrazine

2-iodo-6-(dimethylamino)pyrazine

2-iodo-6-allyloxypyrazine

2-(6-iodo-pyrazin-2-yl)-4-methyl-thiazole-5-carboxylic acid benzylamide

Refernces

• 1、 Jackson, Jeffrey J.,Kobayashi, Hiroyuki,Steffens, Sophia D.,Zakarian, Armen. "10-Step Asymmetric Total Synthesis and Stereochemical Elucidation of (+)-Dragmacidin D". . p. 9971 - 9975. Retrieved 2015.
• 2、 Sun, Shaoyi,Zhang, Zaihui,Kodumuru, Vishnumurthy,Pokrovskaia, Natalia,Fonarev, Julia,Jia, Qi,Leung, Po-Yee,Tran, Jennifer,Ratkay, Leslie G.,McLaren, David G.,Radomski, Chris,Chowdhury, Sultan,Fu, Jianmin,Hubbard, Brian,Winther, Michael D.,Dales, Natalie A.. "Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases". . p. 520 - 525. Retrieved 2014/01/23.