5-nitro-6-amino-1,10-phenanthroline

Base Information

• Chemical Name: 5-nitro-6-amino-1,10-phenanthroline
• CAS No.: 168646-53-5
• Molecular Formula: C12H8N4O2
• Molecular Weight: 240.221
• Hs Code.: 2933990090
• Mol file: 168646-53-5.mol

Synonyms:5-Amino-6-nitro-1,10-phenanthroline;5-Nitro-6-amino-1,10-phenanthroline;6-Amino-5-nitro-1,10-phenanthroline;1,10-Phenanthrolin-5-amine,6-nitro-;

Chemical Property of 5-nitro-6-amino-1,10-phenanthroline

Chemical Property:

• Boiling Point: 510.9±45.0 °C(Predicted)
• PKA: 3.96±0.10(Predicted)
• PSA: 97.62000
• Density: 1.518±0.06 g/cm3(Predicted)
• LogP: 3.37780

Purity/Quality:

99% ^*data from raw suppliers

5-Nitro-6-amino-1,10-phenanthroline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-nitro-6-amino-1,10-phenanthroline

There total 2 articles about 5-nitro-6-amino-1,10-phenanthroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-Nitro-1,10-phenanthroline (4199-88-6) → 5-nitro-6-amino-1,10-phenanthroline (168646-53-5)

Guidance literature:

With potassium hydroxide; hydroxylamine hydrochloride; In 1,4-dioxane; methanol; ethanol; at 4 - 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2007.09.085

Reference yield:

1,10-Phenanthroline (66-71-7) → 5-nitro-6-amino-1,10-phenanthroline (168646-53-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid

2: hydroxylamine hydrochloride; potassium hydroxide / ethanol / Reflux

With sulfuric acid; hydroxylamine hydrochloride; nitric acid; potassium hydroxide; In ethanol;

DOI:10.1016/j.jinorgbio.2014.07.003

Reference yield: 83.0%

5-nitro-6-amino-1,10-phenanthroline (168646-53-5) → 1,10-o-phenanthroline-5,6-diamine (168646-54-6)

Guidance literature:

With hydrazine hydrate; palladium on activated charcoal;

DOI:10.1039/c39950001799

upstream raw materials:

5-Nitro-1,10-phenanthroline

1,10-Phenanthroline

Downstream raw materials:

1,10-o-phenanthroline-5,6-diamine

1,10-phenanthroline-5,6-dione

Refernces

• 1、 Lu, Xiao-Hui,Shi, Shuo,Yao, Jun-Liang,Gao, Xing,Huang, Hai-Liang,Yao, Tian-Ming. "Two structurally analogous ruthenium complexes as naked-eye and reversible molecular "light switch" for G-quadruplex DNA". . p. 64 - 71. Retrieved 2014.
• 2、 Camren, Heather,Chang, Mei-Yueh,Zeng, Liansheng,McGuire, Mark E.. "Synthesis of novel substituted 1,10-phenanthrolines". . p. 1247 - 1252. Retrieved 1996.
• 3、 Ghosh, Amrita,Mandoli, Amit,Kumar, D. Krishna,Yadav, Narendra Singh,Ghosh, Tamal,Jha, Bhavanath,Thomas, Jim A.,Das, Amitava. "DNA binding and cleavage properties of a newly synthesised Ru(II)-polypyridyl complex". . p. 9312 - 9321. Retrieved 2009.
• 4、 -. "5-nitro-1,10-phnanthroline derivatives and pharmaceutical composition for prevention and treatment of tuberculosis containing the same". Paragraph 0249 - 0253. . Retrieved 2017/08/15.