5-phenyl-2-thioxo-4-iMidazolidinone

Base Information

• Chemical Name: 5-phenyl-2-thioxo-4-iMidazolidinone
• CAS No.: 62420-76-2
• Molecular Formula: C9H8N2OS
• Molecular Weight: 192.241
• Mol file: 62420-76-2.mol

Synonyms:5-Phenyl-2-thiohydantoin;

Chemical Property of 5-phenyl-2-thioxo-4-iMidazolidinone

Chemical Property:

• Density: 1.38 g/cm³

Purity/Quality:

NLT 98% ^*data from raw suppliers

5-PHENYL-2-THIOXO-4-IMIDAZOLIDINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-phenyl-2-thioxo-4-iMidazolidinone

There total 8 articles about 5-phenyl-2-thioxo-4-iMidazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2,2-dihydroxy-1-phenyl-ethanone (1075-06-5) + thiourea (17356-08-0) → 5-phenyl-2-thioxoimidazolidin-4-one (62420-76-2)

Guidance literature:

With acetic acid; at 100 ℃; for 0.333333h;

DOI:10.1016/j.tet.2015.06.104

Reference yield: 81.0%

C11H11ClO2 + thiourea (17356-08-0) → 5-phenyl-2-thioxoimidazolidin-4-one (62420-76-2)

Guidance literature:

C₁₁H₁₁ClO₂; thiourea; In tetrahydrofuran; at 20 - 25 ℃; for 24h;

In ethanol; for 1h; Further stages; Reflux;

DOI:10.1134/S1070363208070268

Reference yield: 76.0%

N-(2-amino-4-phenyl-thiazol-5-yl)-acetamide (54167-89-4) → 5-phenyl-2-thioxoimidazolidin-4-one (62420-76-2)

Guidance literature:

N-(2-amino-4-phenyl-thiazol-5-yl)-acetamide; With hydrogenchloride; water; In ethanol; for 2h; Reflux;

With sodium hydrogencarbonate; In ethanol; water;

DOI:10.1134/S1070363208070268

upstream raw materials:

N-(2-amino-4-phenyl-thiazol-5-yl)-benzamide

phenylglyoxal hydrate

thiourea

hydrogenchloride

Downstream raw materials:

4,4'-diphenyl-2,2'-dithioxo-octahydro-[4,4']biimidazolyl-5,5'-dione

Refernces

• 1、 Balya,Chernega,But,Vasilenko,Brovarets,Drach. "Synthesis of new 2,5-diamino-1,3-thiazole and 2-thiohydantoin derivatives by condensation of N-(2-Aryl-1-chloro-2-oxoethyl) carboxamides with thioureas". experimental part. p. 1427 - 1435. Retrieved 2009/02/07.