4-Methoxy-3-(3-methoxypropoxy)benzenemethanol

Base Information

• Chemical Name: 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol
• CAS No.: 172900-74-2
• Molecular Formula: C12H18O4
• Molecular Weight: 226.273
• Hs Code.: 2909499000
• Mol file: 172900-74-2.mol

Synonyms:4-Methoxy-3-(3-methoxypropoxy)benzylalcohol;[4-Methoxy-3-(3-methoxypropoxy)phenyl]methanol;

Chemical Property of 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol

Chemical Property:

• Refractive Index: 1.508
• Boiling Point: 345.034 °C at 760 mmHg
• Flash Point: 162.471 °C
• PSA: 47.92000
• Density: 1.092 g/cm³
• LogP: 1.60280
• Storage Temp.: 2-8°C
• Solubility.: Dichloromethane, Methanol

Purity/Quality:

99% ^*data from raw suppliers

4-Methoxy-3-(3-methoxypropoxy)benzenemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Aliskiren.

Technology Process of 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol

There total 5 articles about 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-3-(3-methoxypropoxy)benzaldehyde (172900-75-3) → [4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol (172900-74-2)

Guidance literature:

With potassium borohydride; In methanol; at 20 ℃;

DOI:10.1021/op400205k

Reference yield:

3-bromopropanol methyl ether (36865-41-5) + 3-hydroxy-4-methoxybenzyl alcohol (4383-06-6) → [4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol (172900-74-2)

Guidance literature:

With potassium carbonate; In water; acetone;

Reference yield:

3-Methoxy-1-propanol methanesulphonate (127686-58-2) + isovanillin (621-59-0) → [4-methoxy-3-(3-methoxypropoxy)-phenyl]methanol (172900-74-2)

Guidance literature:

3-Methoxy-1-propanol methanesulphonate; isovanillin; With potassium carbonate; In toluene; for 10h; Reflux;

With methanol; sodium tetrahydroborate; at 0 - 30 ℃; for 8h;

upstream raw materials:

4-methoxy-3-(3-methoxypropoxy)benzaldehyde

isovanillin

3-(3-bromopropoxy)-4-methoxybenzaldehyde

3-bromopropanol methyl ether

Downstream raw materials:

(3S,5S)-5-{(1R,3S)-1-bromo-3-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-4-methylpentyl}-dihydro-3-(1-methylethyl)furan-2(3H)-one

(R)-2-[4-methoxy-3-(3-methoxypropoxyl)]phenylmethyl-3-methyl-1-chlorobutane

(2S,4S,5S,7S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-5-azido-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(methoxypropoxy)benzyl)-8-methylnonanamide

(2S,7R)-trans-2-Isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methyl-non-4-enoic acid

Refernces

• 1、 Peters, Byron K.,Liu, Jianguo,Margarita, Cristiana,Andersson, Pher G.. "Formal total synthesis of aliskiren". . p. 7292 - 7296. Retrieved 2015/05/05.
• 2、 -. "AN IMPROVED PROCESS FOR THE PREPARATION OF ALISKIREN". Page/Page column 3; 4; 5; 9; 13. . Retrieved 2013/12/03.