2-Butenoicacid,3-(acetylamino)-,ethylester,(2E)-

Base Information

• Chemical Name: 2-Butenoicacid,3-(acetylamino)-,ethylester,(2E)-
• CAS No.: 23652-67-7
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.196
• Hs Code.: 2924199090
• Mol file: 23652-67-7.mol

Synonyms:2-Butenoicacid, 3-(acetylamino)-, ethyl ester, (E)-; Crotonic acid, 3-acetamido-, ethylester, (E)- (8CI); Ethyl trans-3-(acetamido)-2-butenoate;N-((E)-3-Ethoxy-1-methyl-3-oxo-1-propenyl)acetamide

Chemical Property of 2-Butenoicacid,3-(acetylamino)-,ethylester,(2E)-

Chemical Property:

• PSA: 58.89000
• Density: 1.047
• LogP: 1.42970
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(E)-Ethyl3-acetamidobut-2-enoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Butenoicacid,3-(acetylamino)-,ethylester,(2E)-

There total 32 articles about 2-Butenoicacid,3-(acetylamino)-,ethylester,(2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

acetic anhydride (108-24-7) + ethyl 3-aminobut-2-enoate (626-34-6) → ethyl (Z)-β-acetylaminobut-2-enoate (23652-67-7,55572-47-9,23652-56-4)

Guidance literature:

at 90 ℃; for 0.0166667h; Sealed tube; Microwave irradiation; Green chemistry;

DOI:10.21577/0103-5053.20160265

Reference yield: 62.0%

acetamide (60-35-5) + (Z)-3-iodo-but-2-enoic acid ethyl ester (34450-61-8,34450-62-9) → ethyl (Z)-β-acetylaminobut-2-enoate (23652-67-7,55572-47-9,23652-56-4)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; In tetrahydrofuran; at 70 ℃; for 6h;

DOI:10.1021/ol035355c

Reference yield: 61.0%

acetamide (60-35-5) + ethyl acetoacetate (141-97-9) → ethyl (Z/E)-β-acetylaminobut-2-enoate (23652-56-4,23652-67-7,55572-47-9)

Guidance literature:

With boron trifluoride diethyl etherate; In cyclohexane; for 24h; Reagent/catalyst; Reflux;

upstream raw materials:

acetic anhydride

ethyl aminocrotonate

acetamide

ethyl acetoacetate

Downstream raw materials:

ethyl 3-aminobut-2-enoate

2,4-dimethyloxazole-5-ylcarboxylate ethyl ester

ethyl 2,6-dimethyl-4-phenylpyridine-3-carboxylate

ethyl 2-(1-acetyl-4,5-diphenyl-1H-pyrrol-2-yl)ethanoate

Refernces

• 1、 Zhao, Ting-Ting,Song, Jiang-Long,Hong, Feng-Qing,Xia, Jian-Sheng,Li, Jian-Jun. "Highly efficient and facile synthesis of β-enaminones catalyzed by diphenylammonium triflate". . p. 2857 - 2868. Retrieved 2019/08/21.
• 2、 Li, Xiuxiu,You, Cai,Li, Shuailong,Lv, Hui,Zhang, Xumu. "Nickel-catalyzed enantioselective hydrogenation of β-(acylamino)acrylates: Synthesis of chiral β-amino acid derivatives". supporting information. p. 5130 - 5133. Retrieved 2017/11/06.