10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide

Base Information

• Chemical Name: 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide
• CAS No.: 952740-00-0
• Molecular Formula: C₁₇H₁₄N₂O₃
• Molecular Weight: 294.31
• Mol file: 952740-00-0.mol

Synonyms:

Chemical Property of 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide

Chemical Property:

• Melting Point: >200°C

Purity/Quality:

>95% ^*data from raw suppliers

10-Acetoxy-5H-dibenz[b,f]azepine-5-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 10-Acetoxy-5H-dibenz[b,f]azepine-5-carboxamide is an intermediate in the synthesis of Oxacarbazepine (O869250) related compounds.

Technology Process of 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide

There total 2 articles about 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

oxcarbazepine (28721-07-5) + acetic anhydride (108-24-7) → 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide (952740-00-0)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 20 ℃; for 4.16h;

Reference yield:

10-methoxy-5H-dibenzo[b,f]azepine (4698-11-7) → 10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide (952740-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 0 - 25 °C

1.2: 60 - 65 °C

2.1: pyridine / dichloromethane / 6 h / 25 °C

With pyridine; In dichloromethane;

DOI:10.1002/jhet.4281

Reference yield:

10-acetoxy-5H-dibenzo[b,f]azepine-5-carboxamide (952740-00-0) → eslicarbazepine acetate (186694-45-1,236395-14-5)

Guidance literature:

With hydrogen; Rh/DuanPhos complex; In MeTHF; at 20 ℃; under 38787.1 Torr; Product distribution / selectivity;

upstream raw materials:

oxcarbazepine

acetic anhydride

10-methoxy-5H-dibenzo[b,f]azepine

Downstream raw materials:

eslicarbazepine acetate

(+)-Licarbazepine acetate

Refernces

• 1、 -. "PREPARATION OF ESLICARBAZEPINE AND RELATED COMPOUNDS BY ASYMMETRIC HYDROGENATION". Page/Page column 12-13. . Retrieved 2008/06/13.