ethyl 5-(4-hydroxyphenyl)pentanoate

Base Information

• Chemical Name: ethyl 5-(4-hydroxyphenyl)pentanoate
• CAS No.: 154044-13-0
• Molecular Formula: C13H18 O3
• Molecular Weight: 222.28
• Hs Code.: 2918290000
• Mol file: 154044-13-0.mol

Synonyms:Ethyl5-(4-hydroxyphenyl)pentanoate

Chemical Property of ethyl 5-(4-hydroxyphenyl)pentanoate

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.518
• Boiling Point: 344.977°C at 760 mmHg
• Flash Point: 141.747°C
• PSA: 46.53000
• Density: 1.075g/cm³
• LogP: 2.66810

Purity/Quality:

99% ^*data from raw suppliers

ETHYL 5-(4-HYDROXYPHENYL)PENTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 5-(4-hydroxyphenyl)pentanoate

There total 5 articles about ethyl 5-(4-hydroxyphenyl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethanol (64-17-5) + 5-(4'-hydroxyphenyl)pentanoic acid (4654-08-4) → ethyl 5-(4-(hydroxyl)phenyl)pentanoate (154044-13-0)

Guidance literature:

With sulfuric acid; at 90 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c00618

Reference yield:

5-(4-methoxyphenyl)pentanoic acid (7508-04-5) → ethyl 5-(4-(hydroxyl)phenyl)pentanoate (154044-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide / water / 12 h / Reflux; Inert atmosphere; Green chemistry

2: sulfuric acid / 12 h / 20 °C / Inert atmosphere

With sulfuric acid; hydrogen bromide; In water;

DOI:10.1039/c5ob01636c

Reference yield:

methoxybenzene (100-66-3) → ethyl 5-(4-(hydroxyl)phenyl)pentanoate (154044-13-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / nitrobenzene / 3 h / 0 - 100 °C / Inert atmosphere

2: acetic acid; palladium 10% on activated carbon; hydrogen / 12 h / 20 °C / 760.05 Torr / Inert atmosphere

3: hydrogen bromide / water / 12 h / Reflux; Inert atmosphere; Green chemistry

4: sulfuric acid / 12 h / 20 °C / Inert atmosphere

With aluminum (III) chloride; sulfuric acid; palladium 10% on activated carbon; hydrogen bromide; hydrogen; acetic acid; In water; nitrobenzene; 1: |Friedel-Crafts Acylation;

DOI:10.1039/c5ob01636c

upstream raw materials:

ethanol

5-(4'-hydroxyphenyl)pentanoic acid

5-(4-methoxyphenyl)pentanoic acid

methoxybenzene

Downstream raw materials:

5-{4-[(3-fluorobenzyl)oxy]phenyl}pentanoic acid

Refernces

• 1、 Schierle, Simone,Neumann, Sebastian,Heitel, Pascal,Willems, Sabine,Kaiser, Astrid,Pollinger, Julius,Merk, Daniel. "Design and Structural Optimization of Dual FXR/PPARδActivators". supporting information. p. 8369 - 8379. Retrieved 2020/08/12.