6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine

Base Information

• Chemical Name: 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine
• CAS No.: 871792-60-8
• Molecular Formula: C₆H₇N₃
• Molecular Weight: 121.142
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00599641
• Wikidata: Q72466103
• Mol file: 871792-60-8.mol

Synonyms:6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine;871792-60-8;5H,6H,7H-PYRROLO[3,4-B]PYRAZINE;MFCD12755773;SCHEMBL846820;DTXSID00599641;AKOS006343581;AB65657;HS-3076;SY018653;DB-031934;CS-0060730;F12463

Chemical Property of 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine

Chemical Property:

• Vapor Pressure: 0.181mmHg at 25°C
• Refractive Index: 1.574
• Boiling Point: 211.6 °C at 760 mmHg
• PKA: 6.39±0.20(Predicted)
• Flash Point: 81.8 °C
• PSA: 37.81000
• Density: 1.199 g/cm³
• LogP: 0.40860
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 121.063997236
• Heavy Atom Count: 9
• Complexity: 92.5

Purity/Quality:

98%min ^*data from raw suppliers

6,7-Dihydro-5h-pyrrolo[3,4-b]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=NC=CN=C2CN1
• Uses: 6,7-Dihydro-5h-pyrrolo[3,4-b]pyrazine is a useful reagent in the preparation of Gli1 inhibitors, which are useful as therapeutic agents in the treatment of neurological and non-CNS disorders.

Technology Process of 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine

There total 2 articles about 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H21N3 (1107627-28-0) → 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine (871792-60-8)

Guidance literature:

C₂₅H₂₁N₃; With hydrogenchloride; In methanol; for 2h;

With ammonia; In methanol; dichloromethane;

Reference yield:

→ 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine (871792-60-8)

Guidance literature:

upstream raw materials:

C₂₅H₂₁N₃

Refernces

• 1、 -. "AMINOTETRAHYDROPYRANS AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES". Page/Page column 36. . Retrieved 2010/11/28.