(2R,5S)-1-Benzyl-2,5-dimethylpiperazine

Base Information

• Chemical Name: (2R,5S)-1-Benzyl-2,5-dimethylpiperazine
• CAS No.: 216532-43-3
• Molecular Formula: C13H20N2
• Molecular Weight: 204.315
• Mol file: 216532-43-3.mol

Synonyms:piperazine, 2,5-dimethyl-1-(phenylmethyl)-, (2R,5S)-;LogP

Chemical Property of (2R,5S)-1-Benzyl-2,5-dimethylpiperazine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.516
• Boiling Point: 291.506 °C at 760 mmHg
• PKA: 9.35±0.60(Predicted)
• Flash Point: 109.461 °C
• PSA: 15.27000
• Density: 0.964 g/cm³
• LogP: 2.13550

Purity/Quality:

98%min ^*data from raw suppliers

(2R,5S)-1-Benzyl-2,5-dimethyl-piperazine 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2R,5S)-1-Benzyl-2,5-dimethylpiperazine

There total 8 articles about (2R,5S)-1-Benzyl-2,5-dimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3S,6R)-4-benzyl-3,6-dimethylpiperazine-2,5-dione (1072102-01-2) → (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 80 ℃; for 5.66667h; Cooling with ice; Inert atmosphere;

Reference yield: 79.0%

(3S,6R)-1-benzyl-3,6-dimethylpiperazine-2,5-dione (262295-89-6) → (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 70 ℃; for 24h;

Reference yield:

benzyl bromide (100-39-0) + 2,5-dimethyl-piperazine (2815-34-1,1119702-25-8) → trans-2R,5S-dimethyl-4-benzyl-piperazine (260254-80-6,3138-88-3,324750-43-8,745031-35-0) + (-)-(2R,5S)-1-benzyl-2,5-dimethylpiperazine (216532-43-3,3138-88-3,324750-43-8,745031-35-0)

Guidance literature:

In ethanol; at 20 ℃;

upstream raw materials:

benzyl chloride

2,5-dimethyl-piperazine

(+/-)-trans-2,5-dimethyl-4-benzyl-piperazine

(3S,6R)-1-benzyl-3,6-dimethylpiperazine-2,5-dione

Downstream raw materials:

4-benzyl-2R,5S-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

C₃₅H₄₅N₃O₃

tert-butyl 5-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazinyl](3-methoxyphenyl)methyl]-1,3-dihydro-2H-isoindole-2-carboxylate

4-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl]-2-fluorobenzonitrile

Refernces

• 1、 -. "3-AMINO-PYRROLO[3,4-C] PYRAZOLE- 5 (1H, 4H, 6H) CARBALDEHYDE DERIVATIVES AS PKC INHIBITORS". Page/Page column 41. . Retrieved 2008/12/08.
• 2、 -. "PIPERAZINE DERIVATIVES AND THEIR USE AS MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION". Page/Page column 78-79. . Retrieved 2010/02/11.