1,4-bis(broMoMethyl)-2-fluorobenzene

Base Information

• Chemical Name: 1,4-bis(broMoMethyl)-2-fluorobenzene
• CAS No.: 69857-33-6
• Molecular Formula: C8H7Br2F
• Molecular Weight: 281.95
• Mol file: 69857-33-6.mol

Synonyms:1-fluoro-2,5-bis(bromomethyl)benzene;Benzene,1,4-bis(bromomethyl)-2-fluoro;

Chemical Property of 1,4-bis(broMoMethyl)-2-fluorobenzene

Chemical Property:

• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.591
• Boiling Point: 274.196 °C at 760 mmHg
• Flash Point: 119.63 °C
• PSA: 0.00000
• Density: 1.847 g/cm³
• LogP: 3.61550

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-bis(broMoMethyl)-2-fluorobenzene

There total 4 articles about 1,4-bis(broMoMethyl)-2-fluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

2-fluoro-1,4-dimethylbenzene (696-01-5) → 1-fluoro-2,5-bis(bromomethyl)benzene (69857-33-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chloroform; for 1.66667h; Heating;

DOI:10.1016/j.ejmech.2004.02.013

Reference yield: 42.0%

4-(bromomethyl)-2-fluoro-1-methylbenzene (145075-44-1) → 1-fluoro-2,5-bis(bromomethyl)benzene (69857-33-6)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In chloroform; for 10h; Heating;

DOI:10.1021/jm070085f

Reference yield:

2,5-Dimethylaniline (95-78-3) → 1-fluoro-2,5-bis(bromomethyl)benzene (69857-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂; HCl / H₂O / 1 h / 5 °C

1.2: 15 percent / NaBF₄ / 20 °C

2.1: 43 percent / N-bromosuccinimide; 2,2'-azobis(isobutyronitrile) / CHCl₃ / 1.67 h / Heating

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium nitrite; In chloroform; water;

DOI:10.1016/j.ejmech.2004.02.013

upstream raw materials:

2-fluoro-1,4-dimethylbenzene

4-(bromomethyl)-2-fluoro-1-methylbenzene

2,5-Dimethylaniline

Downstream raw materials:

dimethyl 5,5'-[(1E,1'E)-(2-fluoro-1,4-phenylene)bis(ethene-2,1-diyl)]bis(2-methoxybenzoate)

(E,E)-1-fluoro-2,5-bis(3-methoxycarbonyl-4-hydroxystyryl)benzene

(4-Cyanomethyl-2-fluoro-phenyl)-acetonitrile

Refernces

• 1、 -. "Sulfur-containing compound based on glutaryl imide skeleton and application of compound". Paragraph 0686-0687. . Retrieved 2020/09/12.
• 2、 Sato, Kumi,Higuchi, Makoto,Iwata, Nobuhisa,Saido, Takaomi C.,Sasamoto, Kazumi. "Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques". . p. 573 - 578. Retrieved 2007/10/03.