Piperazinone, 1-(2-pyridinyl)- (9CI)

Base Information

• Chemical Name: Piperazinone, 1-(2-pyridinyl)- (9CI)
• CAS No.: 345310-98-7
• Molecular Formula: C₉H₁₁N₃O
• Molecular Weight: 177.206
• Hs Code.: 2933990090
• Mol file: 345310-98-7.mol

Synonyms:Piperazinone,1-(2-pyridinyl)- (9CI);1-(Pyridin-2-yl)piperazin-2-one;Piperazinone, 1-(2-pyridinyl);

Chemical Property of Piperazinone, 1-(2-pyridinyl)- (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 432.539 °C at 760 mmHg
• PKA: 7.15±0.20(Predicted)
• Flash Point: 215.392 °C
• PSA: 45.23000
• Density: 1.202 g/cm³
• LogP: 0.41160
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-Pyridin-2-yl-piperazin-2-onedihydrochloride 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Piperazinone, 1-(2-pyridinyl)- (9CI)

There total 5 articles about Piperazinone, 1-(2-pyridinyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-(2-hydroxyethylamino)-N-pyridin-2-yl-acetamide (345310-96-5) + tributylphosphine (998-40-3) + di-tert-butyl (E)-azodicarboxylate (870-50-8) → 1-(2-pyridyl)piperazin-2-one (345310-98-7)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; MeOH-NH₃; diethyl ether;

Reference yield: 46.0%

4-phenylmethyl-1-(2-pyridinyl)piperazin-2-one (374795-58-1) → 1-(2-pyridyl)piperazin-2-one (345310-98-7)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In methanol; for 4h; Heating / reflux;

Reference yield:

4-benzyloxycarbonyl-1-pyridin-2-ylpiperazin-2-one → 1-(2-pyridyl)piperazin-2-one (345310-98-7)

Guidance literature:

With hydrogen; 20% Pd(OH)2 on carbon; In ethanol; at 20 ℃; for 1h; under 760.051 Torr;

upstream raw materials:

4-phenylmethyl-1-(2-pyridinyl)piperazin-2-one

2-(2-hydroxyethylamino)-N-pyridin-2-yl-acetamide

tributylphosphine

di-tert-butyl (E)-azodicarboxylate

Refernces

• 1、 -. "HYDROXY PYRIDOPYRROLOPYRAZINE DIONE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS". Page/Page column 93. . Retrieved 2010/02/11.
• 2、 -. "Substituted 1,2,3-triazolo[1,5-a]quinazolines for enhancing cognition". . . Retrieved 2008/06/13.