D-(-)-2-CHLOROPHENYLGLYCINE METHYL ESTER HCL

Base Information

• Chemical Name: D-(-)-2-CHLOROPHENYLGLYCINE METHYL ESTER HCL
• CAS No.: 212838-70-5
• Molecular Formula: C₉H₁₀ClNO₂*ClH
• Molecular Weight: 236.098
• Hs Code.: 2922499990
• Mol file: 212838-70-5.mol

Synonyms:Benzeneaceticacid, a-amino-2-chloro-, methyl ester,hydrochloride, (aR)-(9CI)

Chemical Property of D-(-)-2-CHLOROPHENYLGLYCINE METHYL ESTER HCL

Chemical Property:

• PSA: 52.32000
• LogP: 3.01510
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

(R)-(-)-2-ChlorophenylglycineMethylEsterHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-(-)-2-CHLOROPHENYLGLYCINE METHYL ESTER HCL

There total 4 articles about D-(-)-2-CHLOROPHENYLGLYCINE METHYL ESTER HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9) → (+/-)-2-chlorophenylglycine methyl ester hydrochloride (141109-17-3,212838-70-5)

Guidance literature:

With thionyl chloride; at 80 ℃; Inert atmosphere; Cooling with ice;

DOI:10.1021/jacs.9b11422

Reference yield: 88.9%

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate (141109-14-0) → (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt (213018-92-9,212838-70-5)

Guidance literature:

With hydrogenchloride; at 0 - 5 ℃;

Reference yield: 70.0%

→ (S)-(+)-α-(2-thienylethylamino)-α-(2-chlorophenyl)acetic acid methyl ester hydrochloride (141109-18-4,141109-19-5) + (S)-methyl 2-amino-2-(2-chlorophenyl)acetate hydrochloride salt (213018-92-9,212838-70-5)

Guidance literature:

upstream raw materials:

methyl (S)-(+)-2-amino-2-(2-chlorophenyl)acetate

2-amino-(2-chlorophenyl)ethanoic acid

methanol

Downstream raw materials:

C₁₆H₁₄ClNO₂

methyl (S)-2-(2-chlorophenyl)-2-(perfluorophenylsulfonamido)acetate

Refernces

• 1、 -. "Preparation method of (S)-chlorophenylglycine methyl ester hydrochloride". Paragraph 0005; 0006; 0007; 0008. . Retrieved 2017/08/29.
• 2、 -. "Method for preparing 2-thienylethylamine derivatives". . . Retrieved 2008/06/13.