[(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate

Base Information Edit

Chemical Name:[(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate
CAS No.:41639-72-9
Molecular Formula:C31H28O5
Molecular Weight:480.56
Hs Code.:
European Community (EC) Number:682-023-1
Nikkaji Number:J2.876.210K
Mol file:41639-72-9.mol

Synonyms:41639-72-9;[(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate;(3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-5-Phenylpent-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate;SCHEMBL1364975;SCHEMBL1364978;AKOS015896655;AC-24762;(3abeta,6abeta)-4beta-(3-Oxo-5-phenyl-1-pentenyl)-5alpha-(4-biphenylylcarbonyloxy)hexahydro-2H-cyclopenta[b]furan-2-one;(3aR,4R,5R,6aS)-2-oxo-4-[(1E)-3-oxo-5-phenylpent-1-en-1-yl]-hexahydro-2H-cyclopenta[b]furan-5-yl [1,1'-biphenyl]-4-carboxylate;(3aR,4R,5R,6aS)-4-(3-oxo-5-phenyl-1E-pentenyl)-5-(4-phenylbenzoyloxy)-hexahydro-2H-cyclopenta[b]furan-2-one;(3aR,4R,5R,6aS)-hexahydro-4-(3-oxo-5-phenyl-1E-pentenyl)-5-(p-phenyl-benzoyloxy)-2H-cyclopenta[b]furan-2-one;(3aR,4R,5R,6aS)-hexahydro-4-(3-oxo-5-phenyl-1E-pentenyl)-5-(p-phenylbenzoyloxy)-2H-cyclopenta[b]furan-2-one

Suppliers and Price of [(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
[1,1''-Biphenyl]-4-carboxylicAcid(3aR,4R,5R,6aS)-Hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]-2H-cyclopenta[b]furan-5-ylester
50mg
$ 140.00

Biosynth Carbosynth
Biphenyl-4-carboxylic acid2-oxo-4-(3-oxo-5-phenyl-pent-1-enyl)-hexahydro-cyclopenta[b]furan-5-ylester
5 mg
$ 117.00

Biosynth Carbosynth
Biphenyl-4-carboxylic acid2-oxo-4-(3-oxo-5-phenyl-pent-1-enyl)-hexahydro-cyclopenta[b]furan-5-ylester
2 mg
$ 59.00

Biosynth Carbosynth
Biphenyl-4-carboxylic acid2-oxo-4-(3-oxo-5-phenyl-pent-1-enyl)-hexahydro-cyclopenta[b]furan-5-ylester
50 mg
$ 704.00

Biosynth Carbosynth
Biphenyl-4-carboxylic acid2-oxo-4-(3-oxo-5-phenyl-pent-1-enyl)-hexahydro-cyclopenta[b]furan-5-ylester
25 mg
$ 405.00

Biosynth Carbosynth
Biphenyl-4-carboxylic acid2-oxo-4-(3-oxo-5-phenyl-pent-1-enyl)-hexahydro-cyclopenta[b]furan-5-ylester
10 mg
$ 203.00

AK Scientific
[1,1'-Biphenyl]-4-carboxylicacid(3AR,4R,5R,6AS)-hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-pentenyl]-2H-cyclopenta[b]furan-5-ylester
50mg
$ 1000.00

AK Scientific
[1,1'-Biphenyl]-4-carboxylicacid(3AR,4R,5R,6AS)-hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-pentenyl]-2H-cyclopenta[b]furan-5-ylester
5mg
$ 207.00

Total 41 raw suppliers

Chemical Property of [(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate Edit

Chemical Property:

Melting Point:130-131 °C
Boiling Point:695.232 °C at 760 mmHg
Flash Point:294.694 °C
PSA：69.67000
Density:1.261 g/cm³
LogP:5.58870
Solubility.:DCM, Ethyl Acetate
XLogP3:5.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:9
Exact Mass:480.19367399
Heavy Atom Count:36
Complexity:798

Purity/Quality:

98%,99%, ^*data from raw suppliers

[1,1''-Biphenyl]-4-carboxylicAcid(3aR,4R,5R,6aS)-Hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]-2H-cyclopenta[b]furan-5-ylester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2C(CC(=O)O2)C(C1OC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)C=CC(=O)CCC5=CC=CC=C5
Isomeric SMILES:C1[C@H]2[C@H](CC(=O)O2)[C@H]([C@@H]1OC(=O)C3=CC=C(C=C3)C4=CC=CC=C4)/C=C/C(=O)CCC5=CC=CC=C5
Uses [1,1''-Biphenyl]-4-carboxylic Acid (3aR,4R,5R,6aS)-Hexahydro-2-oxo-4-[(1E)-3-oxo-5-phenyl-1-penten-1-yl]-2H-cyclopenta[b]furan-5-yl ester is an intermediate in the synthesis of Latanoprost (L177280) related analogues used in the treatment of glaucoma and various degenerative eye diseases.

Technology Process of [(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate

There total 11 articles about [(3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-phenylpent-1-enyl]-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] 4-phenylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 41162-19-0
dimethyl(2-oxo-4-phenylbutyl)phosphonate

: 38754-71-1
(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate

: 41639-72-9
(1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

Guidance literature:: dimethyl(2-oxo-4-phenylbutyl)phosphonate; With potassium carbonate; In isopropyl alcohol; at 25 ℃; for 0.5h;

(3aR,4R,5R,6aS)-4-formyl-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl biphenyl-4-carboxylate; In isopropyl alcohol; at 25 ℃; for 5h; Temperature;

Reference yield: 90.0%

: 1251949-15-1
C₃₃H₃₀O₆

: 41639-72-9
(1S,5R,6R,7R)-6-(3-oxo-5-phenyl-1E-pentenyl)-7-<(4-phenylbenzoyl)oxy>-2-oxabicyclo<3.3.0>octan-3-one

Guidance literature:: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); tert-butyl alcohol; In water; butanone; at 20 ℃; for 23h;
DOI:10.1016/j.tet.2010.07.069