1-methyl-1H-imidazol-2-amine

Base Information

• Chemical Name: 1-methyl-1H-imidazol-2-amine
• CAS No.: 6646-51-1
• Molecular Formula: C4H7 N3
• Molecular Weight: 97.1197
• Hs Code.: 2933290090
• Mol file: 6646-51-1.mol

Synonyms:Imidazole,2-amino-1-methyl- (7CI,8CI); 1-Methyl-1H-imidazol-2-ylamine;1-Methyl-2-aminoimidazole; 2-Amino-1-methylimidazole

Chemical Property of 1-methyl-1H-imidazol-2-amine

Chemical Property:

• Vapor Pressure: 0.017mmHg at 25°C
• Boiling Point: 255.146oC at 760 mmHg
• PKA: 8.53±0.25(Predicted)
• Flash Point: 108.109oC
• PSA: 43.84000
• Density: 1.224g/cm3
• LogP: 0.58350
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Methyl-1H-imidazol-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-Methyl-1H-imidazol-2-amine, is an intermediate in the synthesis of variety of antibacterial and antitumor agents.

Technology Process of 1-methyl-1H-imidazol-2-amine

There total 6 articles about 1-methyl-1H-imidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1H-imidazol-2-amine (7720-39-0) + methyl iodide (74-88-4) → 1-methyl-2-aminoimidazole (6646-51-1)

Guidance literature:

With copper(l) iodide; 8-quinolinol; sodium t-butanolate; In methanol; at 50 ℃; for 36h; Solvent;

Reference yield: 45.0%

2-lithium-N-methylimidazole (51081-36-8) → 1-methyl-2-aminoimidazole (6646-51-1)

Guidance literature:

With 1-azidostyrene; In tetrahydrofuran; for 2h; from -78 deg.C to room temp.;

DOI:10.1016/S0040-4039(00)86925-7

Reference yield: 17.0%

1-methyl-2-nitroimidazole (1671-82-5,176738-19-5) → 1-methyl-2-aminoimidazole (6646-51-1)

Guidance literature:

With iron; acetic acid; at 80 ℃;

upstream raw materials:

2-lithium-N-methylimidazole

1H-imidazol-2-amine

methyl iodide

bromocyane

Downstream raw materials:

C₁₀H₁₁N₃

Refernces

• 1、 -. "COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS". Page/Page column 160-161. . Retrieved 2020/08/22.
• 2、 Das, Ranajit,Banerjee, Mainak,Rai, Rakesh Kumar,Karri, Ramesh,Roy, Gouriprasanna. "Metal-free C(sp2)-H functionalization of azoles: K2CO3/I2-mediated oxidation, imination, and amination". . p. 4243 - 4260. Retrieved 2018/06/22.