Cbz-Gly-Tyr-NH₂

Base Information

• Chemical Name: Cbz-Gly-Tyr-NH₂
• CAS No.: 19790-44-4
• Molecular Formula: C₁₉H₂₁N₃O₅
• Molecular Weight: 371.393
• Mol file: 19790-44-4.mol

Synonyms:

Chemical Property of Cbz-Gly-Tyr-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cbz-Gly-Tyr-NH₂

There total 4 articles about Cbz-Gly-Tyr-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.3%

N(α)-Cbz-glycine p-guanidinophenyl ester + L-Tyr-NH2 (4985-46-0) → C7H9N3O*H(1+) + Cbz-Gly-Tyr-NH2 (19790-44-4,17263-44-4)

Guidance literature:

With sodium chloride; calcium chloride; papain; In N,N-dimethyl-formamide; at 25 ℃; for 0.416667h; pH=8; aq. buffer; Enzymatic reaction;

DOI:10.1002/cbic.201100267

Reference yield: 1.0%

Cbz-G-Y-OH (7801-35-6) → Cbz-Gly-Tyr-NH2 (19790-44-4,17263-44-4)

Guidance literature:

With orange flavedo peptide amidase; ammonium bicarbonate; In water; acetonitrile; at 40 ℃; for 72h;

DOI:10.1002/(SICI)1521-3773(19980803)37:13/14<1885::AID-ANIE1885>3.0.CO;2-C

Reference yield:

C19H20N2O6*H3N → Cbz-Gly-Tyr-NH2 (19790-44-4,17263-44-4)

Guidance literature:

With Bacillus licheniformis serine endoprotease; ammonia; In 1,4-dioxane; N,N-dimethyl-formamide; tert-butyl alcohol; at 50 ℃; for 16h; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.tetlet.2012.05.039

upstream raw materials:

N-(N-benzyloxycarbonyl-glycyl)-L-tyrosine ethyl ester

Cbz-G-Y-OH

L-Tyr-NH₂

Downstream raw materials:

C₂₈H₃₀N₄O₆

N-benzyloxycarbonylglycyl-L-tyrosine methyl ester

Cbz-G-Y-OH

Cbz-Gly-Tyr-OCH(CH₃)₂

Refernces

• 1、 de Beer, Roseri J.A.C.,Zarzycka, Barbara,Amatdjais-Groenen, Helene I.V.,Jans, Sander C.B.,Nuijens, Timo,Quaedflieg, Peter J.L.M.,van Delft, Floris L.,Nabuurs, Sander B.,Rutjes, Floris P.J.T.. "Papain-catalyzed peptide bond formation: Enzyme-specific activation with guanidinophenyl esters". experimental part. p. 2201 - 2207. Retrieved 2012/05/05.