methyl-2-amino-2-cyclopropyla cetate hydrochloride

Base Information

• Chemical Name: methyl-2-amino-2-cyclopropyla cetate hydrochloride
• CAS No.: 535936-86-8
• Molecular Formula: C6H11NO2.ClH
• Molecular Weight: 165.62
• Hs Code.: 2922499990
• Mol file: 535936-86-8.mol

Synonyms:Cyclopropaneaceticacid, a-amino-, methyl ester, hydrochloride(9CI);Methyl (amino)(cyclopropyl)acetate hydrochloride;

Chemical Property of methyl-2-amino-2-cyclopropyla cetate hydrochloride

Chemical Property:

• Vapor Pressure: 2.21mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 162ºC at 760 mmHg
• Flash Point: 36ºC
• PSA: 52.32000
• Density: 1.147g/cm3
• LogP: 1.39900
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl2-amino-2-cyclopropylacetatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl-2-amino-2-cyclopropyla cetate hydrochloride

There total 2 articles about methyl-2-amino-2-cyclopropyla cetate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

methanol (67-56-1) + (S)-2-amino-2-cyclopropyl acetic acid (15785-26-9) → 2-cyclopropylglycine methyl ester hydrochloride (535936-86-8)

Guidance literature:

With thionyl chloride; at 0 - 70 ℃; for 16h;

DOI:10.1021/jacs.1c11266

Reference yield:

L-cyclopropylglycine (10294-18-5) → 2-cyclopropylglycine methyl ester hydrochloride (535936-86-8)

Guidance literature:

With thionyl chloride; In methanol;

Reference yield: 85.0%

benzaldehyde (100-52-7) + 2-cyclopropylglycine methyl ester hydrochloride (535936-86-8) → methyl N-benzylidene cyclopropyl glycine (118317-25-2)

Guidance literature:

With magnesium sulfate; triethylamine; In dichloromethane; for 16h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85931-7

upstream raw materials:

L-cyclopropylglycine

methanol

(S)-2-amino-2-cyclopropyl acetic acid

Downstream raw materials:

methyl N-benzylidene cyclopropyl glycine

methyl c-2,4-cyclopropyl-7-phenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate

methyl c-2-cyclopropyl-4,7-diphenyl-6,8-dioxo-3,7-diazabicyclo<3.3.0>octane-r-2-carboxylate

Refernces

• 1、 -. "Substituted aryl 1,4-pyrazine derivatives". . . Retrieved 2008/06/13.