2-VALERYLPYRIDINE

Base Information

• Chemical Name: 2-VALERYLPYRIDINE
• CAS No.: 7137-97-5
• Molecular Formula: C10H13NO
• Molecular Weight: 163.219
• Hs Code.: 2933399090
• Mol file: 7137-97-5.mol

Synonyms:1-Pentanone,1-(2-pyridyl)- (7CI,8CI);1-(2-Pyridyl)-1-pentanone;Butyl 2-pyridyl ketone;1-(pyridin-2-yl)pentan-1-one;1-Pentanone, 1-(2-pyridyl)-;1-Pentanone, 1-(2-pyridinyl)-;

Chemical Property of 2-VALERYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.0239mmHg at 25°C
• Refractive Index: 1.501
• Boiling Point: 248.7 °C at 760 mmHg
• PKA: 3.02±0.10(Predicted)
• Flash Point: 110.6 °C
• PSA: 29.96000
• Density: 0.997 g/cm³
• LogP: 2.45450
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Valerylpyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-VALERYLPYRIDINE

There total 6 articles about 2-VALERYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

6-(pyridin-2-yl)decan-5-one → 1-(pyridin-2-yl)pentan-1-one (7137-97-5) + valeric acid (109-52-4)

Guidance literature:

With oxygen; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetonitrile; at 50 ℃; for 2h; Reagent/catalyst; Schlenk technique; Sealed tube; Irradiation; Glovebox;

DOI:10.1021/acs.orglett.9b01940

Reference yield: 75.0%

pyridine N-oxide (694-59-7) + 5-decyne (1942-46-7) → 1-(pyridin-2-yl)pentan-1-one (7137-97-5)

Guidance literature:

With tetrafluoroboric acid; oxygen; 9-(2-mesityl)-10-methylacridinium perchlorate; In acetonitrile; at 50 ℃; for 12h; Schlenk technique; Irradiation;

DOI:10.1021/acs.orglett.9b01940

Reference yield: 8.0%

n-butyllithium (109-72-8,29786-93-4) + N-phenylpicolinamide (10354-53-7) → 1-(pyridin-2-yl)pentan-1-one (7137-97-5) + 6-butyl-N-phenylpyridine-2-carboxamide (764654-41-3)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -78 ℃; for 2h;

DOI:10.1002/ejoc.200400156

upstream raw materials:

n-butyllithium

N-phenylpicolinamide

pyridine N-oxide

5-decyne

Refernces

• 1、 Xu, Jin-Hui,Wu, Wen-Bin,Wu, Jie. "Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with Alkynes under Anaerobic and Aerobic Conditions". supporting information. p. 5321 - 5325. Retrieved 2019/07/08.