C₉H₁₂N₂O*C₂H₄O₂

Base Information

• Chemical Name: C₉H₁₂N₂O*C₂H₄O₂
• CAS No.: 913058-73-8
• Molecular Formula: C₂H₄O₂*C₉H₁₂N₂O
• Molecular Weight: 224.26
• Mol file: 913058-73-8.mol

Synonyms:

Chemical Property of C₉H₁₂N₂O*C₂H₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₁₂N₂O*C₂H₄O₂

There total 1 articles about C₉H₁₂N₂O*C₂H₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-ethoxy-N'-hydroxybenzenecarboximidamide (879-57-2) + acetic acid (64-19-7,77671-22-8) → C9H12N2O*C2H4O2 (913058-73-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; at 65 ℃; for 8h; under 22502.3 Torr;

DOI:10.1021/jm301159y

Reference yield:

C9H12N2O*C2H4O2 (913058-73-8) + ethyl 4-methyl-3-oxo-pentanoate (7152-15-0) → 2-(2-Ethoxyphenyl)-6-isopropylpyrimid-4(3H)-one (1153409-15-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

DOI:10.1021/jm301159y

Reference yield:

C9H12N2O*C2H4O2 (913058-73-8) → 5-bromo-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one (1229017-09-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

2.1: bromine; pyridine / dichloromethane / 0.17 h / 0 °C

3.1: chlorosulfonic acid / 2 h / 0 °C

3.2: 0.17 h / 0 °C

With pyridine; chlorosulfonic acid; bromine; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm301159y

upstream raw materials:

2-ethoxy-N'-hydroxybenzenecarboximidamide

acetic acid

Downstream raw materials:

2-(2-Ethoxyphenyl)-6-isopropylpyrimid-4(3H)-one

5-bromo-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

5-chloro-6-isopropyl-2-[2-ethoxyl-5-(4-methyl-1-piperazinylsulfonyl)phenyl]pyrimid-4(3H)-one

2-(2-Ethoxyphenyl)-5-bromo-6-isopropylpyrimid-4(3H)-one

Refernces