4-(ETHYLAMINO)-3-NITROPYRIDINE

Base Information

• Chemical Name: 4-(ETHYLAMINO)-3-NITROPYRIDINE
• CAS No.: 562825-95-0
• Molecular Formula: C7H9N3O2
• Molecular Weight: 167.167
• Hs Code.: 2933399090
• Mol file: 562825-95-0.mol

Synonyms:4-(Ethylamino)-3-nitropyridine;

Chemical Property of 4-(ETHYLAMINO)-3-NITROPYRIDINE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.608
• Boiling Point: 309.407 °C at 760 mmHg
• PKA: 4.49±0.36(Predicted)
• Flash Point: 140.924 °C
• PSA: 70.74000
• Density: 1.281 g/cm³
• LogP: 2.01780
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Ethyl-3-nitropyridin-4-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(ETHYLAMINO)-3-NITROPYRIDINE

There total 1 articles about 4-(ETHYLAMINO)-3-NITROPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-3-nitro-pyridine (31872-62-5) + ethylamine (75-04-7,85404-22-4) → ethyl-(3-nitropyridin-4-yl)amine (562825-95-0)

Guidance literature:

In ethanol; water; at 85 ℃; for 2h;

Reference yield: 94.0%

ethyl-(3-nitropyridin-4-yl)amine (562825-95-0) → N4-Ethyl-pyridine-3,4-diamine (146950-67-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; at 21 ℃;

DOI:10.1016/j.bmcl.2005.05.021

Reference yield:

ethyl-(3-nitropyridin-4-yl)amine (562825-95-0) → 1-ethyl-2-phenyl-1H-imidazo[4,5-c]pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / H₂ / Pd/C / 21 °C

2: polyphosphoric acid / Heating

With PPA; hydrogen; palladium on activated charcoal;

DOI:10.1016/j.bmcl.2005.05.021

upstream raw materials:

4-methoxy-3-nitro-pyridine

ethylamine

Downstream raw materials:

N₄-Ethyl-pyridine-3,4-diamine

SB 729743

5-bromo-N4-ethylpyridine-3,4-diamine

(7-bromo-1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)acetonitrile

Refernces

• 1、 Stavenger, Robert A.,Cui, Haifeng,Dowdell, Sarah E.,Franz, Robert G.,Gaitanopoulos, Dimitri E.,Goodman, Krista B.,Hilfiker, Mark A.,Ivy, Robert L.,Leber, Jack D.,Marino Jr., Joseph P.,Oh, Hye-Ja,Viet, Andrew Q.,Xu, Weiwei,Ye, Guosen,Zhang, Daohua,Zhao, Yongdong,Jolivette, Larry J.,Head, Martha S.,Semus, Simon F.,Elkins, Patricia A.,Kirkpatrick, Robert B.,Dul, Edward,Khandekar, Sanjay S.,Yi, Tracey,Jung, David K.,Wright, Lois L.,Smith, Gary K.,Behm, David J.,Doe, Christopher P.,Bentley, Ross,Chen, Zunxuan X.,Hu, Erding,Lee, Dennis. "Discovery of aminofurazan-azabenzimidazoles as inhibitors of rho-kinase with high kinase selectivity and antihypertensive activity". . p. 2 - 5. Retrieved 2007/10/03.
• 2、 -. "CANCER TREATMENT METHOD". Page/Page column 77. . Retrieved 2010/02/11.