6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 885518-49-0
• Molecular Formula: C9H7BrN2O2
• Molecular Weight: 255.071
• Hs Code.: 2933990090
• Mol file: 885518-49-0.mol

Synonyms:6-bromo-4-Indazolecarboxylic acid methyl ester; methyl 6-bromo-1H-indazole-4-carboxylate

Chemical Property of 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• Boiling Point: 395.877 °C at 760 mmHg
• PKA: 11.21±0.40(Predicted)
• Flash Point: 193.22 °C
• PSA: 54.98000
• Density: 1.71 g/cm³
• LogP: 2.11200
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 6-bromo-1H-indazole-4-carboxylate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER

There total 9 articles about 6-BROMO-4-INDAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.7%

methyl 1-acetyl-6-bromo-1H-indazole-4-carboxylate (1346597-55-4) → methyl 6-bromo-1H-indazole-4-carboxylate (885518-49-0)

Guidance literature:

methyl 1-acetyl-6-bromo-1H-indazole-4-carboxylate; With hydrogenchloride; In methanol; water; at 60 ℃; for 8h;

With sodium hydrogencarbonate; In methanol; water; pH=8;

Reference yield: 31.0%

2-methyl-3-amino-5-bromobenzoic acid methyl ester (1000342-11-9) → methyl 6-bromo-1H-indazole-4-carboxylate (885518-49-0)

Guidance literature:

With potassium nitrite; In water; acetic acid; at 20 ℃; for 4h;

DOI:10.1007/s00044-019-02454-x

Reference yield:

methanol (67-56-1) + 6-bromo-1H-indazole-4-carboxylic acid (885523-08-0) → methyl 6-bromo-1H-indazole-4-carboxylate (885518-49-0)

Guidance literature:

With hydrogenchloride; at 70 ℃; for 18h;

upstream raw materials:

methanol

6-bromo-1H-indazole-4-carboxylic acid

5-bromo-2-methyl-3-nitro-benzoic acid

5-bromo-2-methyl-3-nitrobenzoic acid methyl ester

Downstream raw materials:

methyl 6-bromo-1-[(4-methylphenyl)sulfonyl]-1H-indazole-4-carboxylate

methyl 6-bromo-1-(1-methylethyl)-1H-indazole-4-carboxylate

N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-1-isopropyl-6-(4-(morpholinomethyl)phenyl)-1H-indazole-4-carboxamide

1-cyclopentyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-(3-(3-(methylamino)propoxy)phenyl)-1H-indazole-4-carboxamide

Refernces

• 1、 Sawant, Ajay S.,Kamble, Sonali S.,Pisal, Parshuram M.,Meshram, Rohan J.,Sawant, Sanjay S.,Kamble, Vilas A.,Kamble, Vinod T.,Gacche, Rajesh N.. "Synthesis and evaluation of a novel series of 6-bromo-1-cyclopentyl-1H-indazole-4-carboxylic acid-substituted amide derivatives as anticancer, antiangiogenic, and antioxidant agents". . p. 17 - 32. Retrieved 2019/11/14.
• 2、 -. "Pyridone derivatives and its preparation and use". . . Retrieved 2016/10/20.